Literature DB >> 27857976

Autophagy regulates DNA repair by modulating histone ubiquitination.

Yanan Wang1, Wei-Guo Zhu2, Ying Zhao1.   

Abstract

Autophagy is an intracellular degradation system that delivers cytoplasmic constituents to the lysosome. Here, we report that the autophagy receptor and substrate p62/SQSTM1 inhibits DNA double-strand break -induced histone and chromatin ubiquitination, which has a critical role in attracting key repair factors to the break sites.

Entities:  

Keywords:  Autophagy; DNA damage; histone ubiquitination; p62

Year:  2016        PMID： 27857976      PMCID： PMC5068184          DOI： 10.1080/23723556.2016.1214772

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  9 in total

1.  Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice.

Authors:  Masaaki Komatsu; Satoshi Waguri; Masato Koike; Yu-Shin Sou; Takashi Ueno; Taichi Hara; Noboru Mizushima; Jun-Ichi Iwata; Junji Ezaki; Shigeo Murata; Jun Hamazaki; Yasumasa Nishito; Shun-Ichiro Iemura; Tohru Natsume; Toru Yanagawa; Junya Uwayama; Eiji Warabi; Hiroshi Yoshida; Tetsuro Ishii; Akira Kobayashi; Masayuki Yamamoto; Zhenyu Yue; Yasuo Uchiyama; Eiki Kominami; Keiji Tanaka
Journal:  Cell       Date:  2007-12-14       Impact factor: 41.582

2.  RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins.

Authors:  Carsten Doil; Niels Mailand; Simon Bekker-Jensen; Patrice Menard; Dorthe Helena Larsen; Rainer Pepperkok; Jan Ellenberg; Stephanie Panier; Daniel Durocher; Jiri Bartek; Jiri Lukas; Claudia Lukas
Journal:  Cell       Date:  2009-02-06       Impact factor: 41.582

3.  Tandem protein interaction modules organize the ubiquitin-dependent response to DNA double-strand breaks.

Authors:  Stephanie Panier; Yosuke Ichijima; Amélie Fradet-Turcotte; Charles C Y Leung; Lilia Kaustov; Cheryl H Arrowsmith; Daniel Durocher
Journal:  Mol Cell       Date:  2012-06-27       Impact factor: 17.970

4.  RNF168 ubiquitinates K13-15 on H2A/H2AX to drive DNA damage signaling.

Authors:  Francesca Mattiroli; Joseph H A Vissers; Willem J van Dijk; Pauline Ikpa; Elisabetta Citterio; Wim Vermeulen; Jurgen A Marteijn; Titia K Sixma
Journal:  Cell       Date:  2012-09-14       Impact factor: 41.582

5.  Autophagy Regulates Chromatin Ubiquitination in DNA Damage Response through Elimination of SQSTM1/p62.

Authors:  Yanan Wang; Nan Zhang; Luyao Zhang; Ran Li; Wan Fu; Ke Ma; Xue Li; Lina Wang; Jiadong Wang; Hongquan Zhang; Wei Gu; Wei-Guo Zhu; Ying Zhao
Journal:  Mol Cell       Date:  2016-06-23       Impact factor: 17.970

6.  Structural basis for sorting mechanism of p62 in selective autophagy.

Authors:  Yoshinobu Ichimura; Taichi Kumanomidou; Yu-shin Sou; Tsunehiro Mizushima; Junji Ezaki; Takashi Ueno; Eiki Kominami; Takashi Yamane; Keiji Tanaka; Masaaki Komatsu
Journal:  J Biol Chem       Date:  2008-06-04       Impact factor: 5.157

7.  The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage.

Authors:  Grant S Stewart; Stephanie Panier; Kelly Townsend; Abdallah K Al-Hakim; Nadine K Kolas; Edward S Miller; Shinichiro Nakada; Jarkko Ylanko; Signe Olivarius; Megan Mendez; Ceri Oldreive; Jan Wildenhain; Andrea Tagliaferro; Laurence Pelletier; Nadine Taubenheim; Anne Durandy; Philip J Byrd; Tatjana Stankovic; A Malcolm R Taylor; Daniel Durocher
Journal:  Cell       Date:  2009-02-06       Impact factor: 41.582

8.  p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy.

Authors:  Serhiy Pankiv; Terje Høyvarde Clausen; Trond Lamark; Andreas Brech; Jack-Ansgar Bruun; Heidi Outzen; Aud Øvervatn; Geir Bjørkøy; Terje Johansen
Journal:  J Biol Chem       Date:  2007-06-19       Impact factor: 5.157

9.  Loss of autophagy causes a synthetic lethal deficiency in DNA repair.

Authors:  Emma Y Liu; Naihan Xu; Jim O'Prey; Laurence Y Lao; Sanket Joshi; Jaclyn S Long; Margaret O'Prey; Daniel R Croft; Florian Beaumatin; Alice D Baudot; Michaela Mrschtik; Mathias Rosenfeldt; Yaou Zhang; David A Gillespie; Kevin M Ryan
Journal:  Proc Natl Acad Sci U S A       Date:  2015-01-07       Impact factor: 11.205
  9 in total
  1 in total

1.  MARCH6 promotes hepatocellular carcinoma development through up-regulation of ATF2.

Authors:  Jie Sun; Zheng Dong; Zhengyao Chang; Hongfei Liu; Qiyu Jiang; Deyuan Zhang; Shanshan Lu; Xiaodong Jia; Dawei Wu; Aaron Ge; Pan Zhao; Jing Wang; Yinying Lu
Journal:  BMC Cancer       Date:  2021-07-17       Impact factor: 4.430
  1 in total

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