Literature DB >> 27857973

Chromatin-bound MDM2, a new player in metabolism.

Romain Riscal1, Laurent Le Cam1, Laetitia K Linares1.   

Abstract

The oncoprotein MDM2 is recognized as a major negative regulator of the p53 tumor suppressor but growing evidence indicates that its oncogenic activities extend beyond p53. We show that MDM2 is recruited to chromatin independently of p53 to regulate a transcriptional program implicated in amino acid metabolism and redox homeostasis.

Entities:  

Keywords:  Cancer; Mdm2; chromatin; metabolism; redox

Year:  2016        PMID： 27857973      PMCID： PMC5068176          DOI： 10.1080/23723556.2016.1210560

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

1.  The RING domain of Mdm2 mediates histone ubiquitylation and transcriptional repression.

Authors:  Neri Minsky; Moshe Oren
Journal:  Mol Cell       Date:  2004-11-19       Impact factor: 17.970

2.  p53 Protein-mediated regulation of phosphoglycerate dehydrogenase (PHGDH) is crucial for the apoptotic response upon serine starvation.

Authors:  Yang Ou; Shang-Jui Wang; Le Jiang; Bin Zheng; Wei Gu
Journal:  J Biol Chem       Date:  2014-11-17       Impact factor: 5.157

3.  Ferroptosis as a p53-mediated activity during tumour suppression.

Authors:  Le Jiang; Ning Kon; Tongyuan Li; Shang-Jui Wang; Tao Su; Hanina Hibshoosh; Richard Baer; Wei Gu
Journal:  Nature       Date:  2015-03-18       Impact factor: 49.962

Review 4.  Metabolic pathways promoting cancer cell survival and growth.

Authors:  Lindsey K Boroughs; Ralph J DeBerardinis
Journal:  Nat Cell Biol       Date:  2015-03-16       Impact factor: 28.824

5.  MDM2 Associates with Polycomb Repressor Complex 2 and Enhances Stemness-Promoting Chromatin Modifications Independent of p53.

Authors:  Magdalena Wienken; Antje Dickmanns; Alice Nemajerova; Daniela Kramer; Zeynab Najafova; Miriam Weiss; Oleksandra Karpiuk; Moustapha Kassem; Yanping Zhang; Guillermina Lozano; Steven A Johnsen; Ute M Moll; Xin Zhang; Matthias Dobbelstein
Journal:  Mol Cell       Date:  2015-12-31       Impact factor: 17.970

6.  Lack of Evidence for PKM2 Protein Kinase Activity.

Authors:  Aaron M Hosios; Brian P Fiske; Dan Y Gui; Matthew G Vander Heiden
Journal:  Mol Cell       Date:  2015-08-20       Impact factor: 17.970

7.  Bioinformatics analysis of the serine and glycine pathway in cancer cells.

Authors:  Alexey Antonov; Massimiliano Agostini; Maria Morello; Marilena Minieri; Gerry Melino; Ivano Amelio
Journal:  Oncotarget       Date:  2014-11-30

8.  NRF2 regulates serine biosynthesis in non-small cell lung cancer.

Authors:  Gina M DeNicola; Pei-Hsuan Chen; Edouard Mullarky; Jessica A Sudderth; Zeping Hu; David Wu; Hao Tang; Yang Xie; John M Asara; Kenneth E Huffman; Ignacio I Wistuba; John D Minna; Ralph J DeBerardinis; Lewis C Cantley
Journal:  Nat Genet       Date:  2015-10-19       Impact factor: 38.330

9.  Serine Metabolism Supports the Methionine Cycle and DNA/RNA Methylation through De Novo ATP Synthesis in Cancer Cells.

Authors:  Oliver D K Maddocks; Christiaan F Labuschagne; Peter D Adams; Karen H Vousden
Journal:  Mol Cell       Date:  2016-01-07       Impact factor: 17.970

10.  Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells.

Authors:  Oliver D K Maddocks; Celia R Berkers; Susan M Mason; Liang Zheng; Karen Blyth; Eyal Gottlieb; Karen H Vousden
Journal:  Nature       Date:  2012-12-16       Impact factor: 49.962
  10 in total
  2 in total

Review 1.  Pyruvate kinase M2: A simple molecule with complex functions.

Authors:  Mohammed Alquraishi; Dexter L Puckett; Dina S Alani; Amal S Humidat; Victoria D Frankel; Dallas R Donohoe; Jay Whelan; Ahmed Bettaieb
Journal:  Free Radic Biol Med       Date:  2019-08-08       Impact factor: 7.376

Review 2.  Two Birds with One Stone: NFAT1-MDM2 Dual Inhibitors for Cancer Therapy.

Authors:  Wei Wang; Atif Zafar; Mehrdad Rajaei; Ruiwen Zhang
Journal:  Cells       Date:  2020-05-09       Impact factor: 6.600
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.