Literature DB >> 27857972

Regulation of gene expression and mitochondrial dynamics by SMAD.

Nirav Shah1, Nam Y Lee2.   

Abstract

Mothers against decapentaplegic homolog (SMAD) proteins exert a wide spectrum of transcriptional effects in different cell types and tissues in response to transforming growth factor-β (TGF-β). A recent study demonstrates what is thought to be the first distinct cytoplasmic function for SMAD2 in modulating mitochondrial dynamics and hence reveals new pathophysiological implications for TGF-β signaling.

Entities:  

Keywords:  MFN2; RIN1; SMAD; mitochondria; transforming growth factor beta

Year:  2016        PMID： 27857972      PMCID： PMC5068171          DOI： 10.1080/23723556.2016.1204492

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  8 in total

Review 1.  Mitochondria: dynamic organelles in disease, aging, and development.

Authors:  David C Chan
Journal:  Cell       Date:  2006-06-30       Impact factor: 41.582

2.  TGF-beta induces apoptosis through Smad-mediated expression of DAP-kinase.

Authors:  Chuan-Wei Jang; Chun-Han Chen; Chun-Chieh Chen; Jia-yun Chen; Yi-Hsien Su; Ruey-Hwa Chen
Journal:  Nat Cell Biol       Date:  2002-01       Impact factor: 28.824

Review 3.  TGFβ signalling in context.

Authors:  Joan Massagué
Journal:  Nat Rev Mol Cell Biol       Date:  2012-09-20       Impact factor: 94.444

4.  Mutational analysis of action of mitochondrial fusion factor mitofusin-2.

Authors:  Shinji Honda; Takeshi Aihara; Masayasu Hontani; Katsuhiko Okubo; Shigehisa Hirose
Journal:  J Cell Sci       Date:  2005-06-28       Impact factor: 5.285

5.  The role of dynamin-related protein 1, a mediator of mitochondrial fission, in apoptosis.

Authors:  S Frank; B Gaume; E S Bergmann-Leitner; W W Leitner; E G Robert; F Catez; C L Smith; R J Youle
Journal:  Dev Cell       Date:  2001-10       Impact factor: 12.270

6.  SMAD proteins control DROSHA-mediated microRNA maturation.

Authors:  Brandi N Davis; Aaron C Hilyard; Giorgio Lagna; Akiko Hata
Journal:  Nature       Date:  2008-06-11       Impact factor: 49.962

Review 7.  Smad-dependent and Smad-independent pathways in TGF-beta family signalling.

Authors:  Rik Derynck; Ying E Zhang
Journal:  Nature       Date:  2003-10-09       Impact factor: 49.962

8.  OPA1 requires mitofusin 1 to promote mitochondrial fusion.

Authors:  Sara Cipolat; Olga Martins de Brito; Barbara Dal Zilio; Luca Scorrano
Journal:  Proc Natl Acad Sci U S A       Date:  2004-10-27       Impact factor: 11.205
  8 in total
  1 in total

Review 1.  Mitochondrial Dynamics, ROS, and Cell Signaling: A Blended Overview.

Authors:  Valentina Brillo; Leonardo Chieregato; Luigi Leanza; Silvia Muccioli; Roberto Costa
Journal:  Life (Basel)       Date:  2021-04-10
  1 in total

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