Literature DB >> 27857971

Cyclin D1 promotes tumor cell invasion and metastasis by cytoplasmic mechanisms.

Noel P Fusté1, Francisco Ferrezuelo1, Eloi Garí1.   

Abstract

Amplification of cyclin D1 is a frequent alteration in many cancers of different type and origin. We recently described a novel regulatory axis involving cyclin D1 in the regulation of tumor invasion and metastasis. Membrane-associated cyclin D1-CDK4 complexes promote activation of the small GTPase RAC1 through phosphorylation of the regulatory protein paxillin.

Entities:  

Keywords:  Cdk4; Rac1; cell invasion; cyclin D1; metastasis; paxillin

Year:  2016        PMID： 27857971      PMCID： PMC5068178          DOI： 10.1080/23723556.2016.1203471

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

1.  Cyclin D1/cyclin-dependent kinase 4 interacts with filamin A and affects the migration and invasion potential of breast cancer cells.

Authors:  Zhijiu Zhong; Wen-Shuz Yeow; Chunhua Zou; Richard Wassell; Chenguang Wang; Richard G Pestell; Judy N Quong; Andrew A Quong
Journal:  Cancer Res       Date:  2010-02-23       Impact factor: 12.701

2.  Cyclin D1 induction of cellular migration requires p27(KIP1).

Authors:  Zhiping Li; Xuanmao Jiao; Chenguang Wang; Xiaoming Ju; Yinan Lu; Liangping Yuan; Michael P Lisanti; Sanjay Katiyar; Richard G Pestell
Journal:  Cancer Res       Date:  2006-10-15       Impact factor: 12.701

3.  Overexpression of cyclin D1 is associated with metastatic prostate cancer to bone.

Authors:  M Drobnjak; I Osman; H I Scher; M Fazzari; C Cordon-Cardo
Journal:  Clin Cancer Res       Date:  2000-05       Impact factor: 12.531

4.  Cyclin D1 regulates cellular migration through the inhibition of thrombospondin 1 and ROCK signaling.

Authors:  Zhiping Li; Chenguang Wang; Xuanmao Jiao; Yinan Lu; Maofu Fu; Andrew A Quong; Chip Dye; Jianguo Yang; Maozheng Dai; Xiaoming Ju; Xueping Zhang; Anping Li; Peter Burbelo; E Richard Stanley; Richard G Pestell
Journal:  Mol Cell Biol       Date:  2006-06       Impact factor: 4.272

5.  Phosphorylation-dependent ubiquitination of cyclin D1 by the SCF(FBX4-alphaB crystallin) complex.

Authors:  Douglas I Lin; Olena Barbash; K G Suresh Kumar; Jason D Weber; J Wade Harper; Andres J P Klein-Szanto; Anil Rustgi; Serge Y Fuchs; J Alan Diehl
Journal:  Mol Cell       Date:  2006-11-03       Impact factor: 17.970

6.  Cyclin D1 interacts and collaborates with Ral GTPases enhancing cell detachment and motility.

Authors:  R M H Fernández; M Ruiz-Miró; X Dolcet; M Aldea; E Garí
Journal:  Oncogene       Date:  2011-01-17       Impact factor: 9.867

Review 7.  Nuclear cyclin D1: an oncogenic driver in human cancer.

Authors:  Jong Kyong Kim; J Alan Diehl
Journal:  J Cell Physiol       Date:  2009-08       Impact factor: 6.384

8.  Characterization of cytoplasmic cyclin D1 as a marker of invasiveness in cancer.

Authors:  Noel P Fusté; Esmeralda Castelblanco; Isidre Felip; Maria Santacana; Rita Fernández-Hernández; Sònia Gatius; Neus Pedraza; Judit Pallarés; Tània Cemeli; Joan Valls; Marc Tarres; Francisco Ferrezuelo; Xavier Dolcet; Xavier Matias-Guiu; Eloi Garí
Journal:  Oncotarget       Date:  2016-05-10

9.  The ZO-1-associated Y-box factor ZONAB regulates epithelial cell proliferation and cell density.

Authors:  Maria S Balda; Michelle D Garrett; Karl Matter
Journal:  J Cell Biol       Date:  2003-02-03       Impact factor: 10.539

10.  Cytoplasmic cyclin D1 regulates cell invasion and metastasis through the phosphorylation of paxillin.

Authors:  Noel P Fusté; Rita Fernández-Hernández; Tània Cemeli; Cristina Mirantes; Neus Pedraza; Marta Rafel; Jordi Torres-Rosell; Neus Colomina; Francisco Ferrezuelo; Xavier Dolcet; Eloi Garí
Journal:  Nat Commun       Date:  2016-05-16       Impact factor: 14.919
  10 in total
  4 in total

Review 1.  Low-Molecular-Weight Cyclin E in Human Cancer: Cellular Consequences and Opportunities for Targeted Therapies.

Authors:  Joseph A Caruso; Mylinh T Duong; Jason P W Carey; Kelly K Hunt; Khandan Keyomarsi
Journal:  Cancer Res       Date:  2018-09-07       Impact factor: 12.701

2.  Nano-curcumin's suppression of breast cancer cells (MCF7) through the inhibition of cyclinD1 expression.

Authors:  Sare Hosseini; Jamshidkhan Chamani; Mohammad Reza Hadipanah; Negar Ebadpour; Amir Sajjad Hojjati; Mohammad Hasan Mohammadzadeh; Hamid Reza Rahimi
Journal:  Breast Cancer (Dove Med Press)       Date:  2019-03-13

Review 3.  Molecular crosstalk between cancer and neurodegenerative diseases.

Authors:  Jiyeon Seo; Mikyoung Park
Journal:  Cell Mol Life Sci       Date:  2019-12-28       Impact factor: 9.261

4.  Targeting human epidermal growth factor receptor 2 enhances radiosensitivity and reduces the metastatic potential of Lewis lung carcinoma cells.

Authors:  Yun Tien; Chiao-Ling Tsai; Wei-Hsien Hou; Yun Chiang; Feng-Ming Hsu; Yu-Chieh Tsai; Jason Chia-Hsien Cheng
Journal:  Radiat Oncol       Date:  2020-03-06       Impact factor: 3.481
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.