Literature DB >> 27857969

A novel role for DNA single-strand breaks in senescence and neoplastic escape of epithelial cells.

Joe Nassour1, Corinne Abbadie2.   

Abstract

In contrast to fibroblasts, epithelial cells spontaneously escape from senescence and develop clones of mutated, transformed, and tumorigenic cells. Recently, we revealed that accumulation of unrepaired DNA single-strand breaks is a trigger of the p16 (CDKN2)-dependent cell cycle arrest pathway in senescent epithelial cells and also the mutagenic motor of post-senescence neoplastic escape.

Entities:  

Keywords:  Cancerogenesis; DNA single-strand breaks; XRCC1; keratincytes; oxidative stress; p16; p38MAPK; senescence

Year:  2016        PMID： 27857969      PMCID： PMC5068179          DOI： 10.1080/23723556.2016.1190885

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

Review 1.  The signals and pathways activating cellular senescence.

Authors:  Ittai Ben-Porath; Robert A Weinberg
Journal:  Int J Biochem Cell Biol       Date:  2004-12-30       Impact factor: 5.085

2.  Senescence-associated oxidative DNA damage promotes the generation of neoplastic cells.

Authors:  Karo Gosselin; Sébastien Martien; Albin Pourtier; Chantal Vercamer; Peter Ostoich; Luc Morat; Laure Sabatier; Laurence Duprez; Claire T'kint de Roodenbeke; Eric Gilson; Nicolas Malaquin; Nicolas Wernert; Predrag Slijepcevic; Marjan Ashtari; Fazia Chelli; Emeric Deruy; Bernard Vandenbunder; Yvan De Launoit; Corinne Abbadie
Journal:  Cancer Res       Date:  2009-10-13       Impact factor: 12.701

3.  Normal human mammary epithelial cells spontaneously escape senescence and acquire genomic changes.

Authors:  S R Romanov; B K Kozakiewicz; C R Holst; M R Stampfer; L M Haupt; T D Tlsty
Journal:  Nature       Date:  2001-02-01       Impact factor: 49.962

Review 4.  Cellular senescence and tumor suppressor gene p16.

Authors:  Hani Rayess; Marilene B Wang; Eri S Srivatsan
Journal:  Int J Cancer       Date:  2011-12-05       Impact factor: 7.396

5.  Involvement of Rel/nuclear factor-kappaB transcription factors in keratinocyte senescence.

Authors:  David Bernard; Karo Gosselin; Didier Monte; Chantal Vercamer; Fatima Bouali; Albin Pourtier; Bernard Vandenbunder; Corinne Abbadie
Journal:  Cancer Res       Date:  2004-01-15       Impact factor: 12.701

Review 6.  DNA single-strand break repair.

Authors:  Keith W Caldecott
Journal:  Exp Cell Res       Date:  2014-08-28       Impact factor: 3.905

7.  Identification of a gene signature of a pre-transformation process by senescence evasion in normal human epidermal keratinocytes.

Authors:  Nathalie Martin; Clara Salazar-Cardozo; Chantal Vercamer; Louise Ott; Guillemette Marot; Predrag Slijepcevic; Corinne Abbadie; Olivier Pluquet
Journal:  Mol Cancer       Date:  2014-06-14       Impact factor: 27.401

8.  Level of macroautophagy drives senescent keratinocytes into cell death or neoplastic evasion.

Authors:  E Deruy; J Nassour; N Martin; C Vercamer; N Malaquin; J Bertout; F Chelli; A Pourtier; O Pluquet; C Abbadie
Journal:  Cell Death Dis       Date:  2014-12-18       Impact factor: 8.469

Review 9.  Irreparable telomeric DNA damage and persistent DDR signalling as a shared causative mechanism of cellular senescence and ageing.

Authors:  Francesca Rossiello; Utz Herbig; Maria Pia Longhese; Marzia Fumagalli; Fabrizio d'Adda di Fagagna
Journal:  Curr Opin Genet Dev       Date:  2014-08-11       Impact factor: 5.578

10.  Defective DNA single-strand break repair is responsible for senescence and neoplastic escape of epithelial cells.

Authors:  Joe Nassour; Sébastien Martien; Nathalie Martin; Emeric Deruy; Elisa Tomellini; Nicolas Malaquin; Fatima Bouali; Laure Sabatier; Nicolas Wernert; Sébastien Pinte; Eric Gilson; Albin Pourtier; Olivier Pluquet; Corinne Abbadie
Journal:  Nat Commun       Date:  2016-01-29       Impact factor: 14.919
  10 in total
  2 in total

Review 1.  Skin Aging, Cellular Senescence and Natural Polyphenols.

Authors:  Erika Csekes; Lucia Račková
Journal:  Int J Mol Sci       Date:  2021-11-23       Impact factor: 5.923

Review 2.  Flavonoids in Skin Senescence Prevention and Treatment.

Authors:  Anna Domaszewska-Szostek; Monika Puzianowska-Kuźnicka; Alina Kuryłowicz
Journal:  Int J Mol Sci       Date:  2021-06-25       Impact factor: 5.923
  2 in total

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