Literature DB >> 2785788

Inhibition of HIV-1 replication and syncytium formation by synthetic CD4 peptides.

Y Hayashi1, K Ikuta, N Fujii, K Ezawa, S Kato.   

Abstract

Only one peptide of CD4 (amino acid residues 70-132) among 16 synthetic peptide fragments selectively inhibited HIV-1 replication and HIV-1-induced syncytium formation. Several smaller peptides within this region did not show any activity, except for the peptide (86-132) which showed somewhat lower activity.

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Year:  1989        PMID： 2785788     DOI： 10.1007/bf01311123

Source DB:  PubMed          Journal:  Arch Virol        ISSN： 0304-8608            Impact factor:   2.574


  22 in total

1.  HIV infection is blocked in vitro by recombinant soluble CD4.

Authors:  R A Fisher; J M Bertonis; W Meier; V A Johnson; D S Costopoulos; T Liu; R Tizard; B D Walker; M S Hirsch; R T Schooley
Journal:  Nature       Date:  1988-01-07       Impact factor: 49.962

2.  Soluble CD4 molecules neutralize human immunodeficiency virus type 1.

Authors:  A Traunecker; W Lüke; K Karjalainen
Journal:  Nature       Date:  1988-01-07       Impact factor: 49.962

3.  A soluble CD4 protein selectively inhibits HIV replication and syncytium formation.

Authors:  R E Hussey; N E Richardson; M Kowalski; N R Brown; H C Chang; R F Siliciano; T Dorfman; B Walker; J Sodroski; E L Reinherz
Journal:  Nature       Date:  1988-01-07       Impact factor: 49.962

4.  The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain.

Authors:  P J Maddon; A G Dalgleish; J S McDougal; P R Clapham; R A Weiss; R Axel
Journal:  Cell       Date:  1986-11-07       Impact factor: 41.582

5.  The isolation and nucleotide sequence of a cDNA encoding the T cell surface protein T4: a new member of the immunoglobulin gene family.

Authors:  P J Maddon; D R Littman; M Godfrey; D E Maddon; L Chess; R Axel
Journal:  Cell       Date:  1985-08       Impact factor: 41.582

6.  A soluble recombinant polypeptide comprising the amino-terminal half of the extracellular region of the CD4 molecule contains an active binding site for human immunodeficiency virus.

Authors:  E A Berger; T R Fuerst; B Moss
Journal:  Proc Natl Acad Sci U S A       Date:  1988-04       Impact factor: 11.205

7.  Clonal analysis of human cytotoxic T lymphocytes: T4+ and T8+ effector T cells recognize products of different major histocompatibility complex regions.

Authors:  S C Meuer; S F Schlossman; E L Reinherz
Journal:  Proc Natl Acad Sci U S A       Date:  1982-07       Impact factor: 11.205

8.  The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus.

Authors:  A G Dalgleish; P C Beverley; P R Clapham; D H Crawford; M F Greaves; R A Weiss
Journal:  Nature       Date:  1984 Dec 20-1985 Jan 2       Impact factor: 49.962

9.  Location and chemical synthesis of a binding site for HIV-1 on the CD4 protein.

Authors:  B A Jameson; P E Rao; L I Kong; B H Hahn; G M Shaw; L E Hood; S B Kent
Journal:  Science       Date:  1988-06-03       Impact factor: 47.728

10.  Possible involvement of the OKT4 molecule in T cell recognition of class II HLA antigens. Evidence from studies of cytotoxic T lymphocytes specific for SB antigens.

Authors:  W E Biddison; P E Rao; M A Talle; G Goldstein; S Shaw
Journal:  J Exp Med       Date:  1982-10-01       Impact factor: 14.307
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  6 in total

1.  Blocking of human immunodeficiency virus infection depends on cell density and viral stock age.

Authors:  S P Layne; M J Merges; J L Spouge; M Dembo; P L Nara
Journal:  J Virol       Date:  1991-06       Impact factor: 5.103

2.  Adaptation of human immunodeficiency virus type 1 to cells expressing a binding-deficient CD4 mutant (lysine 46 to aspartic acid).

Authors:  H R Choe; J Sodroski
Journal:  J Virol       Date:  1995-05       Impact factor: 5.103

3.  Production of infectious particles from defective human immunodeficiency virus type 1 (HIV-1)-producing cell clones by superinfection with infectious HIV-1.

Authors:  M Yunoki; K Maotani-Imai; H Kusuda; M Motoyama; S Miyake; H Imai; Y S Shin; S Kato; K Sano; C Morita
Journal:  Arch Virol       Date:  1991       Impact factor: 2.574

4.  Stimulation of glycoprotein gp120 dissociation from the envelope glycoprotein complex of human immunodeficiency virus type 1 by soluble CD4 and CD4 peptide derivatives: implications for the role of the complementarity-determining region 3-like region in membrane fusion.

Authors:  E A Berger; J D Lifson; L E Eiden
Journal:  Proc Natl Acad Sci U S A       Date:  1991-09-15       Impact factor: 11.205

5.  CD4 molecules with a diversity of mutations encompassing the CDR3 region efficiently support human immunodeficiency virus type 1 envelope glycoprotein-mediated cell fusion.

Authors:  C C Broder; E A Berger
Journal:  J Virol       Date:  1993-02       Impact factor: 5.103

6.  Determinants of human immunodeficiency virus type 1 entry in the CDR2 loop of the CD4 glycoprotein.

Authors:  D Brand; K Srinivasan; J Sodroski
Journal:  J Virol       Date:  1995-01       Impact factor: 5.103
  6 in total

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