Qian Zhang1, Yuanyuan Wang2, Xiaona Xin3, Ya Zhang2, Dujia Liu3, Zuoqi Peng2, Yuan He2, Jihong Xu2, Xu Ma4. 1. Beijing University of Chinese Medicine, Bei San Huan East Road, Chaoyang District, Beijing 100029, People's Republic of China; National Research Institute for Family Planning, 12 Da Hui Temple Road, Haidian District, Beijing 100181, People's Republic of China; Graduate School of Peking Union Medical College, Dongdan San Tiao, Dongcheng District, Beijing 100730, People's Republic of China. 2. National Research Institute for Family Planning, 12 Da Hui Temple Road, Haidian District, Beijing 100181, People's Republic of China. 3. National Research Institute for Family Planning, 12 Da Hui Temple Road, Haidian District, Beijing 100181, People's Republic of China; Graduate School of Peking Union Medical College, Dongdan San Tiao, Dongcheng District, Beijing 100730, People's Republic of China. 4. National Research Institute for Family Planning, 12 Da Hui Temple Road, Haidian District, Beijing 100181, People's Republic of China; Graduate School of Peking Union Medical College, Dongdan San Tiao, Dongcheng District, Beijing 100730, People's Republic of China. Electronic address: maxupumc@163.com.
Abstract
OBJECTIVE: To investigate the effect of folic acid (FA) supplementation on the risks of preterm delivery (PTD) and small for gestational age births (SGA). DATA SOURCES: Cohort studies were identified from MEDLINE, EMBASE, the Cochrane Library, CINAHL, and CBM from inception to January 2015. PARTICIPANTS AND INCLUDED STUDIES: Healthy women who want to get pregnancy or being pregnant. MAIN OUTCOME MEASURES: PTD and SGA. RESULTS: The association of FA and PTD was significant when supplement initiated after pregnancy (RR=0.68, 95%CI, 0.52-0.90), whereas no effect was founded if the initiation time was before conception (RR=0.89, 95%CI, 0.80-1.01). The results for the association between FA supplementation and SGA showed significant protective effect: initiated before conception (RR=0.70, 95%CI, 0.57-0.85) and initiated after conception (RR=0.84, 95%CI, 0.81-0.89). CONCLUSION: Folic acid supplementation is associated with a significant reduction on the risk of PTD when initiated after conception. It can also protect fetus from SGA.
OBJECTIVE: To investigate the effect of folic acid (FA) supplementation on the risks of preterm delivery (PTD) and small for gestational age births (SGA). DATA SOURCES: Cohort studies were identified from MEDLINE, EMBASE, the Cochrane Library, CINAHL, and CBM from inception to January 2015. PARTICIPANTS AND INCLUDED STUDIES: Healthy women who want to get pregnancy or being pregnant. MAIN OUTCOME MEASURES: PTD and SGA. RESULTS: The association of FA and PTD was significant when supplement initiated after pregnancy (RR=0.68, 95%CI, 0.52-0.90), whereas no effect was founded if the initiation time was before conception (RR=0.89, 95%CI, 0.80-1.01). The results for the association between FA supplementation and SGA showed significant protective effect: initiated before conception (RR=0.70, 95%CI, 0.57-0.85) and initiated after conception (RR=0.84, 95%CI, 0.81-0.89). CONCLUSION:Folic acid supplementation is associated with a significant reduction on the risk of PTD when initiated after conception. It can also protect fetus from SGA.
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