Yu Wang1, Zhi-Qiang Cui2, Tian-Bao Luo3, Long Liu1. 1. Department of Orthopaedics, Peking University First Hospital, Beijing 100034, PR China. 2. Department of Orthopaedics, Tsinghua University Second Hospital, Beijing 100049, PR China. Electronic address: zhiqiang_czq@163.com. 3. Department of Orthopaedics, Tsinghua University Second Hospital, Beijing 100049, PR China.
Abstract
OBJECTIVE: This paper aimed to elucidate the correlations of VDR and VDBP polymorphisms with susceptibility to adolescent idiopathic scoliosis (AIS) and efficacy of brace treatment. METHODS: AIS patients and healthy controls were enrolled. Lumbar spine bone mineral density (LSBMD) and femoral neck bone mineral density (FNBMD) were detected by dual energy X-ray absorptiometry. VDR and VDBP polymorphisms were detected by PCR-RFLP. Efficacy of brace treatment was evaluated by Cobb measurement. RESULTS: The frequencies of Bsm I Bb genotype and B allele, and rs222020 CC genotype and C allele in the AIS patients were higher than in the controls. After treatment, the correction rates of average Cobb angle, AVT, AVR and TS in patients with Bsm I Bb and VDBP rs222020 CC genotypes were relatively low. CONCLUSION: VDR Bsm I and VDBP rs222020 C>T polymorphisms may be predisposition factors of AIS and the efficacy of brace treatment in AIS patients.
OBJECTIVE: This paper aimed to elucidate the correlations of VDR and VDBP polymorphisms with susceptibility to adolescent idiopathic scoliosis (AIS) and efficacy of brace treatment. METHODS: AIS patients and healthy controls were enrolled. Lumbar spine bone mineral density (LSBMD) and femoral neck bone mineral density (FNBMD) were detected by dual energy X-ray absorptiometry. VDR and VDBP polymorphisms were detected by PCR-RFLP. Efficacy of brace treatment was evaluated by Cobb measurement. RESULTS: The frequencies of Bsm I Bb genotype and B allele, and rs222020 CC genotype and C allele in the AIS patients were higher than in the controls. After treatment, the correction rates of average Cobb angle, AVT, AVR and TS in patients with Bsm I Bb and VDBPrs222020 CC genotypes were relatively low. CONCLUSION:VDR Bsm I and VDBPrs222020 C>T polymorphisms may be predisposition factors of AIS and the efficacy of brace treatment in AIS patients.
Authors: Alexandra Beling; M Timothy Hresko; Leah DeWitt; Patricia E Miller; Sarah A Pitts; John B Emans; Daniel J Hedequist; Michael P Glotzbecker Journal: Spine Deform Date: 2021-03-08
Authors: Matthew A Halanski; Blake Hildahl; Laura A Amundson; Ellen Leiferman; Annette Gendron-Fitzpatrick; Rajeev Chaudhary; Heather M Hartwig-Stokes; Ronald McCabe; Rachel Lenhart; Matthew Chin; Jennifer Birstler; Thomas D Crenshaw Journal: J Bone Joint Surg Am Date: 2018-03-07 Impact factor: 5.284