Mohamed-Amine Jabri1, Kais Rtibi2, Mohsen Sakly3, Lamjed Marzouki2, Hichem Sebai4. 1. Laboratoire de Physiologie Intégrée, Faculté des Sciences de Bizerte, Zarzouna, Université de Carthage, 7021, Tunisia; Laboratoire de Physiologie Fonctionnelle et Valorisation des Bio-Ressources, Institut Supérieur de Biotechnologie de Béja, Université de Jendouba, Avenue Habib Bourguiba, B.P. 382, 9000, Béja, Tunisia. Electronic address: jabri.amino@gmail.com. 2. Laboratoire de Physiologie Fonctionnelle et Valorisation des Bio-Ressources, Institut Supérieur de Biotechnologie de Béja, Université de Jendouba, Avenue Habib Bourguiba, B.P. 382, 9000, Béja, Tunisia. 3. Laboratoire de Physiologie Intégrée, Faculté des Sciences de Bizerte, Zarzouna, Université de Carthage, 7021, Tunisia. 4. Laboratoire de Physiologie Intégrée, Faculté des Sciences de Bizerte, Zarzouna, Université de Carthage, 7021, Tunisia; Laboratoire de Physiologie Fonctionnelle et Valorisation des Bio-Ressources, Institut Supérieur de Biotechnologie de Béja, Université de Jendouba, Avenue Habib Bourguiba, B.P. 382, 9000, Béja, Tunisia.
Abstract
INTRODUCTION: The myrtle (Myrtus communis) belongs to the Myrtaceae family; it is one of the central plants as part of the list of medicinal plants in the Tunisian Pharmacopoeia. Myrtle berry was used for its astringent, tonic, and antiseptic properties, to treat diarrhea, hemorrhoids, and gastrointestinal injury. METHODS: Adult male wistar rats were used to evaluate the normal gastro-intestinal transit and gastric emptying as well as castor oil-induced diarrhea, enteropooling tests, and small intestine oxidative stress. The effect of myrtle berries juice (MBJ) (5 and 10ml/kg, bw. p.o.) was after compared to the loperamide and clonidine effects. RESULTS: MBJ significantly and dose-dependently inhibited the intestinal motility and gastric emptying. We also found that MBJ administration induced a significant dose-dependent protection against diarrhea and intestinal fluid accumulation. Castor oil-induced intestinal hypersecretion was accompanied by an oxidative stress status in the intestine, which was attenuated by MBJ administration. CONCLUSION: We suggest that MBJ had a potent protective effects against castor oil-induced diarrhea in part due, to its antioxidant and antisecretory properties.
INTRODUCTION: The myrtle (Myrtus communis) belongs to the Myrtaceae family; it is one of the central plants as part of the list of medicinal plants in the Tunisian Pharmacopoeia. Myrtle berry was used for its astringent, tonic, and antiseptic properties, to treat diarrhea, hemorrhoids, and gastrointestinal injury. METHODS: Adult male wistar rats were used to evaluate the normal gastro-intestinal transit and gastric emptying as well as castor oil-induced diarrhea, enteropooling tests, and small intestine oxidative stress. The effect of myrtle berries juice (MBJ) (5 and 10ml/kg, bw. p.o.) was after compared to the loperamide and clonidine effects. RESULTS: MBJ significantly and dose-dependently inhibited the intestinal motility and gastric emptying. We also found that MBJ administration induced a significant dose-dependent protection against diarrhea and intestinal fluid accumulation. Castor oil-induced intestinal hypersecretion was accompanied by an oxidative stress status in the intestine, which was attenuated by MBJ administration. CONCLUSION: We suggest that MBJ had a potent protective effects against castor oil-induced diarrhea in part due, to its antioxidant and antisecretory properties.
Authors: Maria De Luca; Daniela Lucchesi; Carlo Ignazio Giovanni Tuberoso; Xavier Fernàndez-Busquets; Antonio Vassallo; Giuseppe Martelli; Anna Maria Fadda; Laura Pucci; Carla Caddeo Journal: Pharmaceutics Date: 2022-04-21 Impact factor: 6.525