Literature DB >> 27855623

Phytogenic Polyphenols as Glycogen Phosphorylase Inhibitors: The Potential of Triterpenes and Flavonoids for Glycaemic Control in Type 2 Diabetes.

Demetres D Leonidas1, Joseph M Hayes2, Atsushi Kato3, Vassiliki T Skamnaki4, Demetra S M Chatzileontiadou4, Anastassia L Kantsadi4, Efthimios Kyriakis4, Ben A Chetter2, George A Stravodimos4.   

Abstract

Glycogen phosphorylase (GP) is a validated pharmaceutical target for the development of antihyperglycaemic agents. Phytogenic polyphenols, mainly flavonoids and pentacyclic triterpenes, have been found to be potent inhibitors of GP. These compounds have both pharmaceutical and nutraceutical potential for glycemic control in diabetes type 2. This review focuses mainly on the most successful (potent) of these compounds discovered to date. The protein-ligand interactions that form the structural basis of their potencies are discussed, highlighting the potential for exploitation of their scaffolds in the future design of new GP inhibitors. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

Entities:  

Keywords:  Alpha-glucosidases; antioxidants; diabetes; flavonoids; glycogen phosphorylase; pentacyclic triterpenes

Mesh：

Substances：

Year:  2017        PMID： 27855623     DOI： 10.2174/0929867324666161118122534

Source DB:  PubMed          Journal:  Curr Med Chem        ISSN： 0929-8673            Impact factor:   4.530


  7 in total

Review 1.  Unfolding Novel Mechanisms of Polyphenol Flavonoids for Better Glycaemic Control: Targeting Pancreatic Islet Amyloid Polypeptide (IAPP).

Authors:  Ivana R Sequeira; Sally D Poppitt
Journal:  Nutrients       Date:  2017-07-21       Impact factor: 5.717

2.  An NMR-Based Metabolomic Approach to Unravel the Preventive Effect of Water-Soluble Extract from Dendrobium officinale Kimura & Migo on Streptozotocin-Induced Diabetes in Mice.

Authors:  Hong Zheng; Linlin Pan; Pengtao Xu; Jianjun Zhu; Ruohan Wang; Wenzong Zhu; Yongsheng Hu; Hongchang Gao
Journal:  Molecules       Date:  2017-09-15       Impact factor: 4.411

3.  Asiatic acid protests against myocardial ischemia/reperfusion injury via modulation of glycometabolism in rat cardiomyocyte.

Authors:  Yang Dai; Ziwei Wang; Minxue Quan; Yanni Lv; Yunman Li; Hong-Bo Xin; Yisong Qian
Journal:  Drug Des Devel Ther       Date:  2018-10-25       Impact factor: 4.162

Review 4.  Flavonoids and Their Anti-Diabetic Effects: Cellular Mechanisms and Effects to Improve Blood Sugar Levels.

Authors:  Raghad Khalid Al-Ishaq; Mariam Abotaleb; Peter Kubatka; Karol Kajo; Dietrich Büsselberg
Journal:  Biomolecules       Date:  2019-09-01

Review 5.  Anthocyanins as Antidiabetic Agents-In Vitro and In Silico Approaches of Preventive and Therapeutic Effects.

Authors:  Hélder Oliveira; Ana Fernandes; Natércia F Brás; Nuno Mateus; Victor de Freitas; Iva Fernandes
Journal:  Molecules       Date:  2020-08-21       Impact factor: 4.411

6.  Physicochemical properties of dietary phytochemicals can predict their passive absorption in the human small intestine.

Authors:  Sophie N B Selby-Pham; Rosalind B Miller; Kate Howell; Frank Dunshea; Louise E Bennett
Journal:  Sci Rep       Date:  2017-05-16       Impact factor: 4.379

7.  Synthesis of New C- and N-β-d-Glucopyranosyl Derivatives of Imidazole, 1,2,3-Triazole and Tetrazole, and Their Evaluation as Inhibitors of Glycogen Phosphorylase.

Authors:  Sándor Kun; Éva Bokor; Ádám Sipos; Tibor Docsa; László Somsák
Journal:  Molecules       Date:  2018-03-15       Impact factor: 4.411
  7 in total

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