Literature DB >> 2785459

Expression of protein kinase C subspecies in human leukemia-lymphoma cell lines.

S Sawamura1, K Ase, N Berry, U Kikkawa, P G McCaffrey, J Minowada, Y Nishizuka.   

Abstract

Expression of protein kinase C (PKC) subspecies was studied in various human leukemia-lymphoma cell lines. The PKC in most cell lines examined was resolved into two major fractions corresponding to type II (beta-sequence) and type III (alpha-sequence) PKC of the rat brain. The amounts of these two subspecies greatly varied among the cell lines. Type I PKC (gamma-sequence) was expressed in none of the cell lines tested, but PKCs with undefined structures were frequently detected. The differential co-expression of several PKC subspecies is presumably related to the state of cell differentiation.

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Year:  1989        PMID： 2785459     DOI： 10.1016/0014-5793(89)81369-9

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  6 in total

1.  Purification of PKC-I, an endogenous protein kinase C inhibitor, and types II and III protein kinase C isoenzymes from human neutrophils.

Authors:  K J Balazovich; E L McEwen; M L Lutzke; L A Boxer; T White
Journal:  Biochem J       Date:  1992-06-01       Impact factor: 3.857

2.  A method for measuring protein kinase C activity in permeabilized T lymphocytes by using peptide substrates. Evidence for multiple pathways of kinase activation.

Authors:  D R Alexander; J D Graves; S C Lucas; D A Cantrell; M J Crumpton
Journal:  Biochem J       Date:  1990-06-01       Impact factor: 3.857

3.  Sustained activation of protein kinase C is essential to HL-60 cell differentiation to macrophage.

Authors:  H Aihara; Y Asaoka; K Yoshida; Y Nishizuka
Journal:  Proc Natl Acad Sci U S A       Date:  1991-12-15       Impact factor: 11.205

4.  Synergistic activation of type III protein kinase C by cis-fatty acid and diacylglycerol.

Authors:  S G Chen; K Murakami
Journal:  Biochem J       Date:  1992-02-15       Impact factor: 3.857

5.  CD45 tyrosine phosphatase-activated p59fyn couples the T cell antigen receptor to pathways of diacylglycerol production, protein kinase C activation and calcium influx.

Authors:  M Shiroo; L Goff; M Biffen; E Shivnan; D Alexander
Journal:  EMBO J       Date:  1992-12       Impact factor: 11.598

6.  Tissue and cellular distribution of the extended family of protein kinase C isoenzymes.

Authors:  W C Wetsel; W A Khan; I Merchenthaler; H Rivera; A E Halpern; H M Phung; A Negro-Vilar; Y A Hannun
Journal:  J Cell Biol       Date:  1992-04       Impact factor: 10.539
  6 in total

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