Wei Wang1, Miao He1, Wenyong Huang1. 1. a Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology , Sun Yat-Sen University , Guangzhou , People's Republic of China.
Abstract
PURPOSE: Many studies have assessed the changes of retinal nerve fiber layer (RNFL) thickness in patients with obstructive sleep apnea syndrome (OSAS), but the results were inconsistent. Therefore, a meta-analysis was performed to evaluate the RNFL changes in OSAS measured in vivo. METHODS: Pertinent studies were identified by a comprehensive search of PubMed, Embase, Web of science, Cochrane library, Scopus, and Chinese biomedical disc databases from inception to August 2016. A fixed effects model was used to pool the weighted mean difference (WMD) and 95% confidence interval (CI) between OSAS group and control group. RESULTS: Seventeen studies were included in the final analysis, with 12 for descriptive analysis and 5 for meta-analysis, involving a total of 1757 eyes (1106 in the OSAS group and 651 in the control group). The RNFL in OSAS was significantly lower than control group, with pooled WMD -3.53 (95%CI: -4.80 to -2.26, P < 0.001) for average RNFL, -3.69 (95%CI:-5.49 to -1.89 P < 0.001) for superior RNFL, -4.66 (95%CI: -6.92 to -2.39, P < 0.001) for inferior RNFL, -3.15 (95%CI:-5.19 to -1.10, P = 0.003) for nasal RNFL, and -2.45 (95%CI: -4.59 to -0.31, P = 0.025) for temporal RNFL. Along with severities of OSAS, a trend of more profound reduction of average RNFL was observed in advanced OSAS, with WMD of average RNFL thickness -1.75 (95%CI:-4.47 to -0.98, P = 0.209) for mild OSAS, -3.54 (95%CI:-6.33 to -0.73, P = 0.013) for moderate OSAS, and -7.17 (95%CI:-10.00 to -4.34, P < 0.001) for severe OSAS. The majority of studies in the descriptive review demonstrated similar findings. CONCLUSION: The OSAS was associated with a reduced RNFL in all quadrants compared to controls. Evaluation of RNFL may serve as a tool for grading severities of OSAS. Considering the limited evidence, the conclusions should be interpreted cautiously.
PURPOSE: Many studies have assessed the changes of retinal nerve fiber layer (RNFL) thickness in patients with obstructive sleep apnea syndrome (OSAS), but the results were inconsistent. Therefore, a meta-analysis was performed to evaluate the RNFL changes in OSAS measured in vivo. METHODS: Pertinent studies were identified by a comprehensive search of PubMed, Embase, Web of science, Cochrane library, Scopus, and Chinese biomedical disc databases from inception to August 2016. A fixed effects model was used to pool the weighted mean difference (WMD) and 95% confidence interval (CI) between OSAS group and control group. RESULTS: Seventeen studies were included in the final analysis, with 12 for descriptive analysis and 5 for meta-analysis, involving a total of 1757 eyes (1106 in the OSAS group and 651 in the control group). The RNFL in OSAS was significantly lower than control group, with pooled WMD -3.53 (95%CI: -4.80 to -2.26, P < 0.001) for average RNFL, -3.69 (95%CI:-5.49 to -1.89 P < 0.001) for superior RNFL, -4.66 (95%CI: -6.92 to -2.39, P < 0.001) for inferior RNFL, -3.15 (95%CI:-5.19 to -1.10, P = 0.003) for nasal RNFL, and -2.45 (95%CI: -4.59 to -0.31, P = 0.025) for temporal RNFL. Along with severities of OSAS, a trend of more profound reduction of average RNFL was observed in advanced OSAS, with WMD of average RNFL thickness -1.75 (95%CI:-4.47 to -0.98, P = 0.209) for mild OSAS, -3.54 (95%CI:-6.33 to -0.73, P = 0.013) for moderate OSAS, and -7.17 (95%CI:-10.00 to -4.34, P < 0.001) for severe OSAS. The majority of studies in the descriptive review demonstrated similar findings. CONCLUSION: The OSAS was associated with a reduced RNFL in all quadrants compared to controls. Evaluation of RNFL may serve as a tool for grading severities of OSAS. Considering the limited evidence, the conclusions should be interpreted cautiously.
Authors: Katherine A Bussan; Whitney L Stuard; Natalia Mussi; Won Lee; Jess T Whitson; Yacine Issioui; Ashley A Rowe; Katherine J Wert; Danielle M Robertson Journal: PLoS One Date: 2022-06-30 Impact factor: 3.752
Authors: Gloria Tejero-Garcés; Francisco J Ascaso; Paula Casas; Maria I Adiego; Peter Baptista; Carlos O'Connor-Reina; Eugenio Vicente; Guillermo Plaza Journal: J Clin Med Date: 2022-02-03 Impact factor: 4.241