Literature DB >> 27853754

Commentary: alpha-synuclein interacts with SOD1 and promotes its oligomerization.

Anika M Helferich1, Pamela J McLean2, Jochen H Weishaupt1, Karin M Danzer1.   

Abstract

Alpha-synuclein and Cu, Zn superoxide dismutase (SOD1) are both aggregation-prone proteins that are associated with Parkinson's disease (PD) and amyotrophic lateral sclerosis (ALS), respectively. Recently, we showed that alpha-synuclein interacts with SOD1 in various cell types and tissues. Using a cell culture model, we also found that alpha-synuclein nucleates the polymerization of SOD1. Here, we discuss the current literature regarding their interaction and their co-localization in aggregates of human post-mortem tissue. Furthermore we comment on the reported alpha-synuclein-induced SOD1 polymerization in terms of cross-seeding effects in neurodegeneration.

Entities:  

Year:  2016        PMID： 27853754      PMCID： PMC5108581          DOI： 10.29245/2572.942x/2016/7.1065

Source DB:  PubMed          Journal:  J Neurol Neuromedicine        ISSN： 2572-942X


  20 in total

1.  Immunohistochemical study on the distribution of alpha-synuclein in the central nervous system of transgenic mice expressing a human Cu/Zn superoxide dismutase mutation.

Authors:  Yoon Hee Chung; Kyeung Min Joo; Myeung Ju Kim; Choong Ik Cha
Journal:  Neurosci Lett       Date:  2003-05-22       Impact factor: 3.046

2.  Cross-seeding effects of amyloid β-protein and α-synuclein.

Authors:  Kenjiro Ono; Ryoichi Takahashi; Tokuhei Ikeda; Masahito Yamada
Journal:  J Neurochem       Date:  2012-07-23       Impact factor: 5.372

3.  On the stability of bovine superoxide dismutase. The effects of metals.

Authors:  H J Forman; I Fridovich
Journal:  J Biol Chem       Date:  1973-04-25       Impact factor: 5.157

4.  Inhibition of amyloid-β plaque formation by α-synuclein.

Authors:  Teresa Bachhuber; Natalie Katzmarski; Joanna F McCarter; Desiree Loreth; Sabina Tahirovic; Frits Kamp; Claudia Abou-Ajram; Brigitte Nuscher; Alberto Serrano-Pozo; Alexandra Müller; Marco Prinz; Harald Steiner; Bradley T Hyman; Christian Haass; Melanie Meyer-Luehmann
Journal:  Nat Med       Date:  2015-06-22       Impact factor: 53.440

5.  Initiation and synergistic fibrillization of tau and alpha-synuclein.

Authors:  Benoit I Giasson; Mark S Forman; Makoto Higuchi; Lawrence I Golbe; Charles L Graves; Paul T Kotzbauer; John Q Trojanowski; Virginia M-Y Lee
Journal:  Science       Date:  2003-04-25       Impact factor: 47.728

Review 6.  The many faces of α-synuclein: from structure and toxicity to therapeutic target.

Authors:  Hilal A Lashuel; Cassia R Overk; Abid Oueslati; Eliezer Masliah
Journal:  Nat Rev Neurosci       Date:  2013-01       Impact factor: 34.870

7.  Cu/Zn superoxide dismutase-like immunoreactivity is present in Lewy bodies from Parkinson disease: a light and electron microscopic immunocytochemical study.

Authors:  K Nishiyama; S Murayama; J Shimizu; Y Ohya; S Kwak; K Asayama; I Kanazawa
Journal:  Acta Neuropathol       Date:  1995       Impact factor: 17.088

8.  C9ORF72 expansions, parkinsonism, and Parkinson disease: a clinicopathologic study.

Authors:  Johnathan Cooper-Knock; Antonina Frolov; J Robin Highley; Gavin Charlesworth; Janine Kirby; Antonio Milano; Judith Hartley; Paul G Ince; Christopher J McDermott; Tammaryn Lashley; Tamas Revesz; Pamela J Shaw; Nicholas W Wood; Oliver Bandmann
Journal:  Neurology       Date:  2013-07-24       Impact factor: 9.910

9.  α-synuclein interacts with SOD1 and promotes its oligomerization.

Authors:  Anika M Helferich; Wolfgang P Ruf; Veselin Grozdanov; Axel Freischmidt; Marisa S Feiler; Lisa Zondler; Albert C Ludolph; Pamela J McLean; Jochen H Weishaupt; Karin M Danzer
Journal:  Mol Neurodegener       Date:  2015-12-08       Impact factor: 14.195

Review 10.  Cross-seeding of misfolded proteins: implications for etiology and pathogenesis of protein misfolding diseases.

Authors:  Rodrigo Morales; Ines Moreno-Gonzalez; Claudio Soto
Journal:  PLoS Pathog       Date:  2013-09-19       Impact factor: 6.823
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  4 in total

Review 1.  The impact of proteostasis dysfunction secondary to environmental and genetic causes on neurodegenerative diseases progression and potential therapeutic intervention.

Authors:  Abdelmagid M Elmatboly; Ahmed M Sherif; Dalia A Deeb; Amira Benmelouka; May N Bin-Jumah; Lotfi Aleya; Mohamed M Abdel-Daim
Journal:  Environ Sci Pollut Res Int       Date:  2020-02-19       Impact factor: 4.223

2.  The H2S Donor Sodium Thiosulfate (Na2S2O3) Does Not Improve Inflammation and Organ Damage After Hemorrhagic Shock in Cardiovascular Healthy Swine.

Authors:  David Alexander Christian Messerer; Holger Gaessler; Andrea Hoffmann; Michael Gröger; Kathrin Benz; Aileen Huhn; Felix Hezel; Enrico Calzia; Peter Radermacher; Thomas Datzmann
Journal:  Front Immunol       Date:  2022-06-16       Impact factor: 8.786

Review 3.  H2S in Critical Illness-A New Horizon for Sodium Thiosulfate?

Authors:  Tamara Merz; Oscar McCook; Cosima Brucker; Christiane Waller; Enrico Calzia; Peter Radermacher; Thomas Datzmann
Journal:  Biomolecules       Date:  2022-04-04

Review 4.  Mitochondrial function and autophagy: integrating proteotoxic, redox, and metabolic stress in Parkinson's disease.

Authors:  Jianhua Zhang; Matilda Lillian Culp; Jason G Craver; Victor Darley-Usmar
Journal:  J Neurochem       Date:  2018-02-14       Impact factor: 5.372
  4 in total

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