| Literature DB >> 27852165 |
Fernanda Carvalho Cagni1, Clarissa Loureiro das Chagas Campêlo1, Daniel Gomes Coimbra1, Mayara Rodrigues Barbosa1, Luiz Gonzaga Oliveira Júnior1, Antônio Braz Silva Neto1, Alessandra Mussi Ribeiro1, Clécio de Oliveira Godeiro Júnior1, Tiago Gomes de Andrade1, Regina Helena Silva1.
Abstract
An association between Parkinson's disease (PD) and brain-derived neurotrophic factor (BDNF) was suggested by several studies, with contradictory results. BDNF is necessary for the survival of dopaminergic neurons in substantia nigra. Val66Met is a common polymorphism of the BDNF gene that affects cognitive and motor processes. The authors studied 104 Brazilian patients with PD and 96 control participants. The G/G genotype was significantly associated with depression and anxiety symptoms and development of PD. This is the first study that associates this genotype with PD.Entities:
Keywords: Anxiety Disorders (Neuropsychiatric Aspects); Depression; Genetics; Parkinson’s Disease
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Year: 2016 PMID： 27852165 DOI： 10.1176/appi.neuropsych.16040062
Source DB: PubMed Journal: J Neuropsychiatry Clin Neurosci ISSN： 0895-0172 Impact factor: 2.198