Literature DB >> 2785049

Molecular control of tissue-specific expression at the mouse TNF locus.

C V Jongeneel1, A N Shakhov, S A Nedospasov, J C Cerottini.   

Abstract

We have examined the patterns of mRNA accumulation and transcription of the tandemly linked genes for tumor necrosis factor (TNF)-beta and TNF-alpha. In spite of their tandem arrangement and close linkage, the two TNF genes utilize separate promoters. Our results show that, while levels of mRNA correlate with patterns of TNF-alpha and TNF-beta secretion by lymphocytes and macrophages, the transcriptional levels of the corresponding genes do not. The TNF-alpha gene is transcribed much more heavily than the TNF-beta gene in T lymphocytes, even though the TNF-beta mRNA is more abundant. Resting T lymphocytes and macrophages, which do not accumulate any TNF mRNA, nevertheless transcribe the TNF-alpha gene actively. On the other hand, the TNF-beta gene is transcriptionally silent in macrophages. Our results are consistent with a model where tissue specificity is controlled transcriptionally, whereas post-transcriptional events differentially control mRNA abundance.

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Year:  1989        PMID： 2785049     DOI： 10.1002/eji.1830190321

Source DB:  PubMed          Journal:  Eur J Immunol        ISSN： 0014-2980            Impact factor:   5.532


  10 in total

Review 1.  Regulation of tumor necrosis factor production by monocyte-macrophages and lymphocytes.

Authors:  G Trinchieri
Journal:  Immunol Res       Date:  1991       Impact factor: 2.829

2.  Chromatin structure and DNase I hypersensitivity in the transcriptionally active and inactive porcine tumor necrosis factor gene locus.

Authors:  P Kuhnert; E Peterhans; U Pauli
Journal:  Nucleic Acids Res       Date:  1992-04-25       Impact factor: 16.971

3.  Protection against lethal toxic shock by targeted disruption of the CD28 gene.

Authors:  B Saha; D M Harlan; K P Lee; C H June; R Abe
Journal:  J Exp Med       Date:  1996-06-01       Impact factor: 14.307

4.  Characterization of a tumor necrosis factor-responsive element which down-regulates the human osteocalcin gene.

Authors:  Y P Li; P Stashenko
Journal:  Mol Cell Biol       Date:  1993-06       Impact factor: 4.272

5.  Constitutive activity of the tumor necrosis factor promoter is canceled by the 3' untranslated region in nonmacrophage cell lines; a trans-dominant factor overcomes this suppressive effect.

Authors:  V Kruys; K Kemmer; A Shakhov; V Jongeneel; B Beutler
Journal:  Proc Natl Acad Sci U S A       Date:  1992-01-15       Impact factor: 11.205

6.  Lymphotoxin activation by human T-cell leukemia virus type I-infected cell lines: role for NF-kappa B.

Authors:  N L Paul; M J Lenardo; K D Novak; T Sarr; W L Tang; N H Ruddle
Journal:  J Virol       Date:  1990-11       Impact factor: 5.103

7.  Kappa B-type enhancers are involved in lipopolysaccharide-mediated transcriptional activation of the tumor necrosis factor alpha gene in primary macrophages.

Authors:  A N Shakhov; M A Collart; P Vassalli; S A Nedospasov; C V Jongeneel
Journal:  J Exp Med       Date:  1990-01-01       Impact factor: 14.307

8.  Insights into the regulation of TNF-alpha production in human mononuclear cells: the effects of non-specific phosphodiesterase inhibition.

Authors:  Jessica Deree; Joilson O Martins; Heidi Melbostad; William H Loomis; Raul Coimbra
Journal:  Clinics (Sao Paulo)       Date:  2008-06       Impact factor: 2.365

9.  Lysozyme is an inducible marker of macrophage activation in murine tissues as demonstrated by in situ hybridization.

Authors:  S Keshav; P Chung; G Milon; S Gordon
Journal:  J Exp Med       Date:  1991-11-01       Impact factor: 14.307

10.  T cell receptor (TCR) engagement leads to activation-induced splicing of tumor necrosis factor (TNF) nuclear pre-mRNA.

Authors:  Y Yang; J F Chang; J R Parnes; C G Fathman
Journal:  J Exp Med       Date:  1998-07-20       Impact factor: 14.307
  10 in total

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