| Literature DB >> 2785021 |
G Beck1, G R Vasta, J J Marchalonis, G S Habicht.
Abstract
1. Eight North American species of tunicates were examined for the presence of interleukin-1 (IL-1) like activity. 2. The tunicates studied produce molecules with readily detectable lymphocyte activation factor (LAF) activity. 3. G50 column chromatography separated molecular species that were directly mitogenic for thymocytes (mol. wt greater than 50,000) from those that were comitogenic in an IL-1 assay (mol. wt 20,000). 4. Tunicate fractions with LAF activity induced increased vascular permeability in rabbit skin. 5. Tunicate LAF activity was neutralized by polyclonal anti-human IL-1 antisera. 6. These data further support the conclusion that IL-1 is an ancient and functionally conserved molecule.Entities:
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Year: 1989 PMID： 2785021 DOI： 10.1016/0305-0491(89)90318-0
Source DB: PubMed Journal: Comp Biochem Physiol B ISSN： 0305-0491