| Literature DB >> 27849602 |
Runze Li1, Jie Chen2,3, Thomas C Cesario4, Xin Wang5, Joshua S Yuan5, Peter M Rentzepis6.
Abstract
In this paper we describe the antibacterial effect of methylene blue, MB, and silver nitrate reacting alone and in combination against five bacterial strains including Serratia marcescens and Escherichia coli bacteria. The data presented suggest that when the two components are combined and react together against bacteria, the effects can be up to three orders of magnitude greater than that of the sum of the two components reacting alone against bacteria. Analysis of the experimental data provides proof that a synergistic mechanism is operative within a dose range when the two components react together, and additive when reacting alone against bacteria.Entities:
Keywords: bacteria; methylene blue; silver ions; synergistic effect
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Year: 2016 PMID: 27849602 PMCID: PMC5137719 DOI: 10.1073/pnas.1611193113
Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN: 0027-8424 Impact factor: 11.205