Maria Helena Baptista Nunes da Silva1, Maria Cristina Korbage de Araujo2, Edna Maria de Albuquerque Diniz3, Maria Esther Jurfest Rivero Ceccon4, Werther Brunow de Carvalho5. 1. MSc from Faculdade de Medicina, Universidade de São Paulo (FMUSP). Assistant Physician, Neonatal Intensive Care Center (CTIN-2), Instituto da Criança, Hospital das Clínicas (HC-FMUSP), São Paulo, SP, Brazil. 2. PhD in Neonatology from FMUSP. Coordinator of Complementary Medicine, Instituto da Criança, HC-FMUSP, São Paulo, SP, Brazil. 3. Associate Professor, FMUSP. Head of Neonatology Research, Hospital Universitário (HU-FMUSP), São Paulo, SP, Brazil. 4. PhD in Neonatology from FMUSP. Head of the CTIN-2, Instituto da Criança, HC-FMUSP, São Paulo, SP, Brazil. 5. Full Professor of Intensive Care/Neonatology at FMUSP and Instituto da Criança, HC-FMUSP, São Paulo, SP, Brazil.
Abstract
OBJECTIVE: : To describe thyroid alterations in term newborns (TNB) with fungal sepsis during NICU hospitalization. METHOD: : The study included six TNB that during the clinical and laboratory manifestations of sepsis with positive cultures for fungus showed changes in thyroid hormones, called low T3 syndrome and low T3-T4 syndrome. TNB that could present hormonal changes caused by disease as those born to mothers with thyroid disease, or who had perinatal asphyxia and major surgeries were excluded. RESULTS: : Of six TNB with fungal sepsis, five had positive culture for Candida albicans and one had positive culture for Candida tropicalis. Low T3 syndrome was observed in two TNB (50%), while T3-T4 syndrome was observed in other two (100%). The four children progressed to septic shock. CONCLUSION: : Fungal sepsis is becoming more common among newborns admitted to NICU. Thyroid insufficiency could be a marker of disease severity with possible need for hormone supplementation.
OBJECTIVE: : To describe thyroid alterations in term newborns (TNB) with fungal sepsis during NICU hospitalization. METHOD: : The study included six TNB that during the clinical and laboratory manifestations of sepsis with positive cultures for fungus showed changes in thyroid hormones, called low T3 syndrome and low T3-T4 syndrome. TNB that could present hormonal changes caused by disease as those born to mothers with thyroid disease, or who had perinatal asphyxia and major surgeries were excluded. RESULTS: : Of six TNB with fungal sepsis, five had positive culture for Candida albicans and one had positive culture for Candida tropicalis. Low T3 syndrome was observed in two TNB (50%), while T3-T4 syndrome was observed in other two (100%). The four children progressed to septic shock. CONCLUSION: : Fungal sepsis is becoming more common among newborns admitted to NICU. Thyroid insufficiency could be a marker of disease severity with possible need for hormone supplementation.
Authors: Apostolos Chatzitomaris; Rudolf Hoermann; John E Midgley; Steffen Hering; Aline Urban; Barbara Dietrich; Assjana Abood; Harald H Klein; Johannes W Dietrich Journal: Front Endocrinol (Lausanne) Date: 2017-07-20 Impact factor: 5.555