Stefano Veraldi1, Giuseppe Micali2, Enzo Berardesca3, Federica Dall'Oglio2, Jo Linda Sinagra3, Elena Guanziroli1. 1. Department of Pathophysiology and Transplantation, Università degli Studi di Milano, I.R.C.C.S. Foundation, Cà Granda Ospedale Maggiore Policlinico, Milan, Italy. 2. Section of Dermatology, Department of Medical and Surgical Specialties, University of Catania, Italy. 3. San Gallicano Dermatological Institute, Rome, Italy.
Abstract
Objective:To evaluate the efficacy and tolerability of a novel hydrogen peroxide-based regimen versus a benzoyl peroxide-based regimen in mild-to-moderate acne. Methods: In this eight-week multicenter study, patients were randomized to either a hydrogen peroxide-based or a benzoyl peroxide-based regimen.The primary outcome measure of clinical response was assessed using the Global Acne Grading System (GAGS) at baseline,four weeks, and eight weeks. At Week 8, a patient self-satisfaction questionnaire was administered. Investigators were also queried at that time regarding assessment of tolerability and cosmetic acceptability. Tolerability was also measured at each visit. Results: Both treatment regimens were associated with improvement of GAGS score at Week 8 compared to baseline (p<0.0001). GAGS score did not differ significantly between the two regimens over the same period (p=0.7765). No significant adverse events were reported or observed in either treatment arm. Both patients and investigators found both regimens to be similarly effective and cosmetically acceptable. Conclusion: A novel hydrogen peroxide-based regimen was shown to be comparable in efficacy, safety, and cosmetic acceptability to a benzoyl peroxide-based regimen in the treatment of mild-to-moderate acne.
RCT Entities:
Objective:To evaluate the efficacy and tolerability of a novel hydrogen peroxide-based regimen versus a benzoyl peroxide-based regimen in mild-to-moderate acne. Methods: In this eight-week multicenter study, patients were randomized to either a hydrogen peroxide-based or a benzoyl peroxide-based regimen.The primary outcome measure of clinical response was assessed using the Global Acne Grading System (GAGS) at baseline,four weeks, and eight weeks. At Week 8, a patient self-satisfaction questionnaire was administered. Investigators were also queried at that time regarding assessment of tolerability and cosmetic acceptability. Tolerability was also measured at each visit. Results: Both treatment regimens were associated with improvement of GAGS score at Week 8 compared to baseline (p<0.0001). GAGS score did not differ significantly between the two regimens over the same period (p=0.7765). No significant adverse events were reported or observed in either treatment arm. Both patients and investigators found both regimens to be similarly effective and cosmetically acceptable. Conclusion: A novel hydrogen peroxide-based regimen was shown to be comparable in efficacy, safety, and cosmetic acceptability to a benzoyl peroxide-based regimen in the treatment of mild-to-moderate acne.
Authors: Harald Gollnick; William Cunliffe; Diane Berson; Brigitte Dreno; Andrew Finlay; James J Leyden; Alan R Shalita; Diane Thiboutot Journal: J Am Acad Dermatol Date: 2003-07 Impact factor: 11.527
Authors: Diane Thiboutot; Harald Gollnick; Vincenzo Bettoli; Brigitte Dréno; Sewon Kang; James J Leyden; Alan R Shalita; Vicente Torres Lozada; Diane Berson; Andrew Finlay; Chee Leok Goh; María Isabel Herane; Ana Kaminsky; Raj Kubba; Alison Layton; Yoshiki Miyachi; Montserrat Perez; Jaime Piquero Martin; Marcia Ramos-E-Silva; Jo Ann See; Neil Shear; John Wolf Journal: J Am Acad Dermatol Date: 2009-05 Impact factor: 11.527