| Literature DB >> 2784719 |
F Pflumio1, P Fonteneau, C Gavériaux, S Cammisuli, F Loor.
Abstract
This article describes the construction and establishment of a double congenic nude, beige C57BL/6 (B6 nu, bg) mouse strain. The mice do not show higher fragility than C57BL/6 nude mice and the double congenic strain can be maintained under conventional mouse housing conditions. Although the B6 nu, bg display a very low natural killer activity which cannot be enhanced by an interferon inducer (poly(I-C], they lack responsiveness to a T cell mitogen (concanavalin A); and they also show extremely low responsiveness to a B cell mitogen (0128: B12 Escherichia coli lipopolysaccharide) probably as a result of combined effects of the beige and nude genes in the C57BL/6 genetic context.Entities:
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Year: 1989 PMID： 2784719 DOI： 10.1016/0008-8749(89)90189-5
Source DB: PubMed Journal: Cell Immunol ISSN： 0008-8749 Impact factor: 4.868