Youssef Kouidrat1, Ahmad Zaitouni2, Ali Amad3, Momar Diouf2, Rachel Desailloud2, Gwenole Loas4, Jean-Daniel Lalau2. 1. Department of Nutrition, AP-HP, Hôpital Maritime de Berck, F-62600 Berck, France; Department of Endocrinology-Nutrition, University of Picardie Jules Verne, F-80054 Amiens, France. Electronic address: youssef.kouidrat@gmail.com. 2. Department of Endocrinology-Nutrition, University of Picardie Jules Verne, F-80054 Amiens, France. 3. Department of Psychiatry, Univ. Lille, CNRS, CHU de Lille, UMR9193-PsychiC-SCALab, F-59000 Lille, France. 4. Department of Psychiatry, Erasme Hospital, ULB, B-1070 Brussels, Belgium.
Abstract
AIM: Although diabetes-related erectile dysfunction (ED) has many etiological factors, little is known about the putative pathophysiological role of advanced glycation end products (AGEs). Skin autofluorescence is a noninvasive marker of AGEs. Recent studies have evidenced a relationship between skin autofluorescence and several complications of diabetes. We hypothesized that AGEs (assessed by skin autofluorescence) are associated with ED in diabetes patients. METHODS: Between March 2014 and April 2015, 42 patients with type 1 diabetes (T1D) and 44 patients with type 2 diabetes (T2D) were consecutively enrolled in a descriptive, cross-sectional study and compared to 54 healthy controls. ED was evaluated via the 5-item version of the International Index of Erectile Function (IIEF-5). Skin autofluorescence was measured on the volar aspect of the arm with an AGE-Reader. RESULTS: Patients with diabetes had a mean±standard deviation age of 50±15 and a mean duration of diabetes of 16±12years. Skin autofluorescence was strongly and significantly correlated with the IIEF-5 score in the T1D subgroup (r=-0.52; P=0.004), the T2D subgroup (r=-0.32; P<0.03) and in the whole group of diabetic patients (r=-0.49; P<0.0001). In multivariate analyses that controlled for potentially confounding clinical and biochemical factors, only skin autofluorescence was still significantly correlated with the IIEF-5 score (P<0.0001). A receiver operating characteristic analysis revealed that a skin autofluorescence value ≥3.2AU determined severe ED with a sensitivity of 60% and a specificity of 87% in diabetic patients. CONCLUSION: Skin autofluorescence is significantly associated with ED in diabetes, independently of classical confounding factors.
AIM: Although diabetes-related erectile dysfunction (ED) has many etiological factors, little is known about the putative pathophysiological role of advanced glycation end products (AGEs). Skin autofluorescence is a noninvasive marker of AGEs. Recent studies have evidenced a relationship between skin autofluorescence and several complications of diabetes. We hypothesized that AGEs (assessed by skin autofluorescence) are associated with ED in diabetespatients. METHODS: Between March 2014 and April 2015, 42 patients with type 1 diabetes (T1D) and 44 patients with type 2 diabetes (T2D) were consecutively enrolled in a descriptive, cross-sectional study and compared to 54 healthy controls. ED was evaluated via the 5-item version of the International Index of Erectile Function (IIEF-5). Skin autofluorescence was measured on the volar aspect of the arm with an AGE-Reader. RESULTS:Patients with diabetes had a mean±standard deviation age of 50±15 and a mean duration of diabetes of 16±12years. Skin autofluorescence was strongly and significantly correlated with the IIEF-5 score in the T1D subgroup (r=-0.52; P=0.004), the T2D subgroup (r=-0.32; P<0.03) and in the whole group of diabeticpatients (r=-0.49; P<0.0001). In multivariate analyses that controlled for potentially confounding clinical and biochemical factors, only skin autofluorescence was still significantly correlated with the IIEF-5 score (P<0.0001). A receiver operating characteristic analysis revealed that a skin autofluorescence value ≥3.2AU determined severe ED with a sensitivity of 60% and a specificity of 87% in diabeticpatients. CONCLUSION: Skin autofluorescence is significantly associated with ED in diabetes, independently of classical confounding factors.
Authors: Mikołaj Kamiński; Michał Kulecki; Paweł Lachowski; Dominika Kasprzak; Ania Kulczycka; Maria Kozłowska; Daria Klause; Aleksandra Uruska; Mateusz Michalski; Dorota Zozulińska-Ziółkiewicz Journal: Int J Angiol Date: 2022-01-13