Literature DB >> 2784681

Enhancement by tetraphenylboron of the interaction of the 1-methyl-4-phenylpyridinium ion (MPP+) with mitochondria.

R R Ramsay1, R J Mehlhorn, T P Singer.   

Abstract

Inhibition of mitochondrial energy production by MPP+ may be the key step in chemically-induced Parkinson's disease. Tetraphenylboron (TPB-) markedly enhances the effect of MPP+. Inhibition of respiration and uptake of MPP+ are accelerated, the former by up to two orders of magnitude. TPB increases the final concentration of MPP+ in the matrix by 2-3 fold, insufficient to explain the rapid inhibition of respiration. TPB- lowers the membrane surface potential by only about 20%, but increases the partitioning of MPP+ into organic solvent by one order of magnitude. TPB- also enhances the effect of MPP+ on inverted membranes, reducing the I50 by an order of magnitude. We suggest that TPB- acts by ion pairing with MPP+ to facilitate penetration into mitochondria as well as access to a hydrophobic inhibition site on NADH dehydrogenase.

Entities:  

Mesh：

Substances：

Year:  1989        PMID： 2784681     DOI： 10.1016/0006-291x(89)92205-5

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  8 in total

Review 1.  Bacterial NADH-quinone oxidoreductases.

Authors:  T Yagi
Journal:  J Bioenerg Biomembr       Date:  1991-04       Impact factor: 2.945

2.  Inhibition of complex I by hydrophobic analogues of N-methyl-4-phenylpyridinium (MPP+) and the use of an ion-selective electrode to measure their accumulation by mitochondria and electron-transport particles.

Authors:  M P Murphy; M J Krueger; S O Sablin; R R Ramsay; T P Singer
Journal:  Biochem J       Date:  1995-03-01       Impact factor: 3.857

3.  Mitochondrial respiratory inhibition by N-methylated beta-carboline derivatives structurally resembling N-methyl-4-phenylpyridine.

Authors:  R Albores; E J Neafsey; G Drucker; J Z Fields; M A Collins
Journal:  Proc Natl Acad Sci U S A       Date:  1990-12       Impact factor: 11.205

4.  Structural dependence of the inhibition of mitochondrial respiration and of NADH oxidase by 1-methyl-4-phenylpyridinium (MPP+) analogs and their energized accumulation by mitochondria.

Authors:  R R Ramsay; S K Youngster; W J Nicklas; K A McKeown; Y Z Jin; R E Heikkila; T P Singer
Journal:  Proc Natl Acad Sci U S A       Date:  1989-12       Impact factor: 11.205

5.  Is complex II involved in the inhibition of mitochondrial respiration by N-methyl-4-phenylpyridinium cation (MMP+) and N-methyl-beta-carbolines?

Authors:  M J Krueger; A K Tan; B A Ackrell; T P Singer
Journal:  Biochem J       Date:  1993-05-01       Impact factor: 3.857

6.  Uptake and accumulation of 1-methyl-4-phenylpyridinium by rat liver mitochondria measured using an ion-selective electrode.

Authors:  G P Davey; K F Tipton; M P Murphy
Journal:  Biochem J       Date:  1992-12-01       Impact factor: 3.857

7.  Effects of partial inhibition of respiratory complex I on H2O 2 production by isolated brain mitochondria in different respiratory states.

Authors:  Luiz G B Michelini; Carlos E Benevento; Franco A Rossato; Edilene S Siqueira-Santos; Roger F Castilho
Journal:  Neurochem Res       Date:  2014-10-07       Impact factor: 3.996

8.  Evidence that the inhibition sites of the neurotoxic amine 1-methyl-4-phenylpyridinium (MPP+) and of the respiratory chain inhibitor piericidin A are the same.

Authors:  R R Ramsay; M J Krueger; S K Youngster; T P Singer
Journal:  Biochem J       Date:  1991-01-15       Impact factor: 3.857
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.