BACKGROUND: We report long-term outcomes of patients treated with primary radiotherapy (RT) or surgery and adjuvant RT for salivary gland malignancies. MATERIALS AND METHODS: From 1964 to 2012, 291 patients received primary RT (n = 67) or RT combined with surgery (n = 224). RESULTS: The 5-, 10-, and 15-year local control, local-regional control, distant metastasis-free survival, cause-specific survival and overall survival rates were 82%, 77% and 73%; 77%, 72% and 67%; 74%, 70% and 70%; 70%, 59% and 54%; and 63%, 47% and 38%, respectively. Per multivariate analysis, combined surgery and RT and T stage impacted local control; overall stage and combined surgery and RT impacted local-regional control; overall stage impacted distant metastasis-free survival; and overall stage, node positivity, clinical nerve invasion, and surgery and RT impacted cause-specific and overall survival. Five percent of patients experienced grade 3 or worse toxicity. CONCLUSION: Combined surgery and RT improves local control, local-regional control, and cause-specific survival compared with primary RT for salivary tumors.
BACKGROUND: We report long-term outcomes of patients treated with primary radiotherapy (RT) or surgery and adjuvant RT for salivary gland malignancies. MATERIALS AND METHODS: From 1964 to 2012, 291 patients received primary RT (n = 67) or RT combined with surgery (n = 224). RESULTS: The 5-, 10-, and 15-year local control, local-regional control, distant metastasis-free survival, cause-specific survival and overall survival rates were 82%, 77% and 73%; 77%, 72% and 67%; 74%, 70% and 70%; 70%, 59% and 54%; and 63%, 47% and 38%, respectively. Per multivariate analysis, combined surgery and RT and T stage impacted local control; overall stage and combined surgery and RT impacted local-regional control; overall stage impacted distant metastasis-free survival; and overall stage, node positivity, clinical nerve invasion, and surgery and RT impacted cause-specific and overall survival. Five percent of patients experienced grade 3 or worse toxicity. CONCLUSION: Combined surgery and RT improves local control, local-regional control, and cause-specific survival compared with primary RT for salivary tumors.
Authors: Francesca De Felice; Valentino Valentini; Marco De Vincentiis; Cira Rosaria Tiziana Di Gioia; Daniela Musio; Aida Angela Tummolo; Ludovica Isabella Ricci; Valeria Converti; Silvia Mezi; Daniela Messineo; Gianluca Tenore; Marco Della Monaca; Massimo Ralli; Francesco Vullo; Andrea Botticelli; Edoardo Brauner; Paolo Priore; Romeo Umberto; Paolo Marchetti; Carlo Della Rocca; Antonella Polimeni; Vincenzo Tombolini Journal: In Vivo Date: 2021 Nov-Dec Impact factor: 2.406
Authors: Sati Akbaba; Kristin Lang; Thomas Held; Klaus Herfarth; Juliane Rieber; Peter Plinkert; Gerd U Auffarth; Stefan Rieken; Juergen Debus; Sebastian Adeberg Journal: Cancer Manag Res Date: 2019-02-01 Impact factor: 3.989
Authors: Benjamin Gravesteijn; Eline Krijkamp; Jan Busschbach; Geert Geleijnse; Isabel Retel Helmrich; Sophie Bruinsma; Céline van Lint; Ernest van Veen; Ewout Steyerberg; Kees Verhoef; Jan van Saase; Hester Lingsma; Rob Baatenburg de Jong Journal: Value Health Date: 2021-03-05 Impact factor: 5.725