| Literature DB >> 27846570 |
Qin Wang1,2, Zecheng Zuo1,3, Xu Wang1,2, Lianfeng Gu1, Takeshi Yoshizumi4, Zhaohe Yang1, Liang Yang1,3, Qing Liu1,2,3, Wei Liu3, Yun-Jeong Han5, Jeong-Il Kim5, Bin Liu6, James A Wohlschlegel7, Minami Matsui4, Yoshito Oka8,4, Chentao Lin8,2.
Abstract
Cryptochromes are blue-light receptors that regulate development and the circadian clock in plants and animals. We found that Arabidopsis cryptochrome 2 (CRY2) undergoes blue light-dependent homodimerization to become physiologically active. We identified BIC1 (blue-light inhibitor of cryptochromes 1) as an inhibitor of plant cryptochromes that binds to CRY2 to suppress the blue light-dependent dimerization, photobody formation, phosphorylation, degradation, and physiological activities of CRY2. We hypothesize that regulated dimerization governs homeostasis of the active cryptochromes in plants and other evolutionary lineages.Entities:
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Year: 2016 PMID： 27846570 PMCID： PMC6180212 DOI： 10.1126/science.aaf9030
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728