Literature DB >> 27845591

Drug-target interaction kinetics: underutilized in drug optimization?

Robert A Copeland1.   

Abstract

Keywords:  drug–target residence time; kinetics; lead optimization; pharmacodynamics; pharmacokinetic–pharmacodynamics relationship

Mesh：

Year:  2016        PMID： 27845591     DOI： 10.4155/fmc-2016-0183

Source DB:  PubMed          Journal:  Future Med Chem        ISSN： 1756-8919            Impact factor:   3.808


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  4 in total

1.  Preparation and evaluation of soluble epoxide hydrolase inhibitors with improved physical properties and potencies for treating diabetic neuropathic pain.

Authors:  Kin Sing Stephen Lee; Jen C Ng; Jun Yang; Sung-Hee Hwang; Christophe Morisseau; Karen Wagner; Bruce D Hammock
Journal:  Bioorg Med Chem       Date:  2020-08-31       Impact factor: 3.641

2.  Simultaneous Target-Mediated Drug Disposition Model for Two Small-Molecule Compounds Competing for Their Pharmacological Target: Soluble Epoxide Hydrolase.

Authors:  Nan Wu; Bruce D Hammock; Kin Sing Stephen Lee; Guohua An
Journal:  J Pharmacol Exp Ther       Date:  2020-04-01       Impact factor: 4.030

3.  Drug-Target Residence Time Affects in Vivo Target Occupancy through Multiple Pathways.

Authors:  Kin Sing Stephen Lee; Jun Yang; Jun Niu; Connie J Ng; Karen M Wagner; Hua Dong; Sean D Kodani; Debin Wan; Christophe Morisseau; Bruce D Hammock
Journal:  ACS Cent Sci       Date:  2019-09-03       Impact factor: 14.553

4.  In Silico Prediction of the Dissociation Rate Constants of Small Chemical Ligands by 3D-Grid-Based VolSurf Method.

Authors:  Shuheng Huang; Linxin Chen; Hu Mei; Duo Zhang; Tingting Shi; Zuyin Kuang; Yu Heng; Lei Xu; Xianchao Pan
Journal:  Int J Mol Sci       Date:  2020-04-02       Impact factor: 5.923
  4 in total

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