Literature DB >> 2784486

A cytotoxic T lymphocyte inhibits acquired immunodeficiency syndrome virus replication in peripheral blood lymphocytes.

H Tsubota1, C I Lord, D I Watkins, C Morimoto, N L Letvin.   

Abstract

CD8+ (suppressor/cytotoxic) lymphocytes block replication of HIV-1 or the simian immunodeficiency virus of macaques (SIVmac) in PBL of infected individuals. We now show that these CD8+ lymphocytes undergo clonal expansion in vivo after AIDS virus infection of the individual, suggesting they may be antigen-specific T cells. These CD8+ cells block replication of virus in autologous but not MHC class I-mismatched PBL. The inhibitory lymphocytes express the integrin family molecule 4B4 and the CTL-associated S6F1 epitope of LFA-1. Finally, physical contact is required for the CD8+ lymphocyte-mediated inhibition of AIDS virus replication, since this inhibitory function is blocked by anti-LFA-1 and anti-CD8 mAbs. These studies suggest that the cell that inhibits AIDS virus replication in PBL of infected individuals is a CTL.

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Year:  1989        PMID： 2784486      PMCID： PMC2189228          DOI： 10.1084/jem.169.4.1421

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  23 in total

Review 1.  Monoclonal antibodies for analysis of the HLA system.

Authors:  F M Brodsky; P Parham; C J Barnstable; M J Crumpton; W F Bodmer
Journal:  Immunol Rev       Date:  1979       Impact factor: 12.988

2.  A novel epitope of the LFA-1 antigen which can distinguish killer effector and suppressor cells in human CD8 cells.

Authors:  C Morimoto; C E Rudd; N L Letvin; S F Schlossman
Journal:  Nature       Date:  1987 Dec 3-9       Impact factor: 49.962

3.  Suppression of simian immunodeficiency virus replication in vitro by CD8+ lymphocytes.

Authors:  M Kannagi; L V Chalifoux; C I Lord; N L Letvin
Journal:  J Immunol       Date:  1988-04-01       Impact factor: 5.422

4.  Major histocompatibility complex class I molecules of nonhuman primates.

Authors:  D I Watkins; M Kannagi; M E Stone; N L Letvin
Journal:  Eur J Immunol       Date:  1988-09       Impact factor: 5.532

5.  The isolation and characterization of the human helper inducer T cell subset.

Authors:  C Morimoto; N L Letvin; A W Boyd; M Hagan; H M Brown; M M Kornacki; S F Schlossman
Journal:  J Immunol       Date:  1985-06       Impact factor: 5.422

6.  Restriction of in vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semiallogeneic system.

Authors:  R M Zinkernagel; P C Doherty
Journal:  Nature       Date:  1974-04-19       Impact factor: 49.962

7.  Human naive and memory T cells: reinterpretation of helper-inducer and suppressor-inducer subsets.

Authors:  M E Sanders; M W Makgoba; S Shaw
Journal:  Immunol Today       Date:  1988 Jul-Aug

8.  Clonal analysis of human cytotoxic T lymphocytes: T4+ and T8+ effector T cells recognize products of different major histocompatibility complex regions.

Authors:  S C Meuer; S F Schlossman; E L Reinherz
Journal:  Proc Natl Acad Sci U S A       Date:  1982-07       Impact factor: 11.205

Review 9.  Human natural lymphocyte effector cells: definition, analysis of activity, and clinical effectiveness.

Authors:  J R Ortaldo; D L Longo
Journal:  J Natl Cancer Inst       Date:  1988-09-07       Impact factor: 13.506

10.  The isolation and characterization of the human suppressor inducer T cell subset.

Authors:  C Morimoto; N L Letvin; J A Distaso; W R Aldrich; S F Schlossman
Journal:  J Immunol       Date:  1985-03       Impact factor: 5.422
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  97 in total

1.  Suppression of HIV replication in the resting CD4+ T cell reservoir by autologous CD8+ T cells: implications for the development of therapeutic strategies.

Authors:  T W Chun; J S Justement; S Moir; C W Hallahan; L A Ehler; S Liu; M McLaughlin; M Dybul; J M Mican; A S Fauci
Journal:  Proc Natl Acad Sci U S A       Date:  2001-01-02       Impact factor: 11.205

2.  The simian immunodeficiency virus envelope glycoprotein contains two epitopes presented by the Mamu-A*01 class I molecule.

Authors:  M Furchner; A L Erickson; T Allen; D I Watkins; A Sette; P R Johnson; C M Walker
Journal:  J Virol       Date:  1999-10       Impact factor: 5.103

3.  Higher macrophage inflammatory protein (MIP)-1alpha and MIP-1beta levels from CD8+ T cells are associated with asymptomatic HIV-1 infection.

Authors:  F Cocchi; A L DeVico; R Yarchoan; R Redfield; F Cleghorn; W A Blattner; A Garzino-Demo; S Colombini-Hatch; D Margolis; R C Gallo
Journal:  Proc Natl Acad Sci U S A       Date:  2000-12-05       Impact factor: 11.205

Review 4.  Cellular and humoral antigenic epitopes in HIV and SIV.

Authors:  D F Nixon; K Broliden; G Ogg; P A Broliden
Journal:  Immunology       Date:  1992-08       Impact factor: 7.397

Review 5.  Role of class I molecules of the major histocompatibility complex in cytotoxic T-cell function in health and disease.

Authors:  A J McMichael
Journal:  Springer Semin Immunopathol       Date:  1992

6.  Ex vivo T cell-based HIV suppression assay to evaluate HIV-specific CD8+ T-cell responses.

Authors:  Asier Sáez-Cirión; So Youn Shin; Pierre Versmisse; Françoise Barré-Sinoussi; Gianfranco Pancino
Journal:  Nat Protoc       Date:  2010-05-13       Impact factor: 13.491

7.  Effects of TH1 and TH2 cytokines on CD8+ cell response against human immunodeficiency virus: implications for long-term survival.

Authors:  E Barker; C E Mackewicz; J A Levy
Journal:  Proc Natl Acad Sci U S A       Date:  1995-11-21       Impact factor: 11.205

8.  Direct injection of a recombinant retroviral vector induces human immunodeficiency virus-specific immune responses in mice and nonhuman primates.

Authors:  M J Irwin; L S Laube; V Lee; M Austin; S Chada; C G Anderson; K Townsend; D J Jolly; J F Warner
Journal:  J Virol       Date:  1994-08       Impact factor: 5.103

9.  Tissue infiltration in a CD8 lymphocytosis syndrome associated with human immunodeficiency virus-1 infection has the phenotypic appearance of an antigenically driven response.

Authors:  S Itescu; J Dalton; H Z Zhang; R Winchester
Journal:  J Clin Invest       Date:  1993-05       Impact factor: 14.808

10.  Rapid screening for Mamu-A1-positive rhesus macaques using a SIVmac Gag peptide-specific cytotoxic T-lymphocyte assay.

Authors:  T Vogel; S Norley; B Beer; R Kurth
Journal:  Immunology       Date:  1995-03       Impact factor: 7.397
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