Qian Liu1,2, Jing Wu2, Wen Shen3, Ran Wei2, Jianhui Jiang4, Jinqun Liang4, Min Chen5, Mei Zhong1, Aihua Yin2. 1. a Department of Obstetrics and Gynecology , Southern Medical University, Nan fang Hospital , Guangzhou , China. 2. b Department of Medical Genetics Center , Guangdong Women and Children Hospital , Guangzhou , China. 3. c Department of Urology , Liuhuaqiao Hospital , Guangzhou , China. 4. d Department of Children Inherited Metabolism and Endocrine , Guangdong Women and Children Hospital , Guangzhou , China. 5. e Department of Prenatal Diagnosis & Fetal Medicine , The Third Affiliated Hospital of Guangzhou Medical University , Guangzhou , China.
Abstract
OBJECTIVE: To analyze the amino acids (AA) and acyl carnitine (AC) profiles in dry blood spot (DBS) specimens of low birth weight (LBW), preterm birth (PTB), and small for gestational age (SGA), and to compare the concentration difference of AA and AC with those without above. METHODS: This is a retrospectively study. Eight thousand nine hundred and seventy-nine uncomplicated pregnant newborns were enrolled into the study. DBS were collected on the third day of life, and concentrations of 11 types of AA, free carnitine and 30 types of AC were detected by using high-performance liquid chromatography tandem mass spectrometry (HPLC-MS). Shapiro-Wilk test and Kruskal-Wallis rank test were applied in statistical analysis. RESULTS: Concentrations of most AA and AC in infants born in SGA were significantly higher than those in non-SGA group, while lower in LBW and PTB groups than those in non-LBW and non-PTB groups (p < 0.05). CONCLUSIONS: The difference of concentration of AA and AC in the subgroups suggested there may be a dysutilization of AA and AC in SGA, but an inborn insufficient of AA and AC in LBW and PTB neonates.
OBJECTIVE: To analyze the amino acids (AA) and acyl carnitine (AC) profiles in dry blood spot (DBS) specimens of low birth weight (LBW), preterm birth (PTB), and small for gestational age (SGA), and to compare the concentration difference of AA and AC with those without above. METHODS: This is a retrospectively study. Eight thousand nine hundred and seventy-nine uncomplicated pregnant newborns were enrolled into the study. DBS were collected on the third day of life, and concentrations of 11 types of AA, free carnitine and 30 types of AC were detected by using high-performance liquid chromatography tandem mass spectrometry (HPLC-MS). Shapiro-Wilk test and Kruskal-Wallis rank test were applied in statistical analysis. RESULTS: Concentrations of most AA and AC in infants born in SGA were significantly higher than those in non-SGA group, while lower in LBW and PTB groups than those in non-LBW and non-PTB groups (p < 0.05). CONCLUSIONS: The difference of concentration of AA and AC in the subgroups suggested there may be a dysutilization of AA and AC in SGA, but an inborn insufficient of AA and AC in LBW and PTB neonates.
Entities:
Keywords:
low birth weight; preterm birth; small for gestational age; “Amino acids/analysis” [Mesh]; “carnitine/analysis” [Mesh]
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