Literature DB >> 27844069

Efficient DBU accelerated synthesis of 18F-labelled trifluoroacetamides.

Antonio Bermejo Gómez1, Miguel A Cortés González2, Marvin Lübcke2, Magnus J Johansson3, Christer Halldin4, Kálmán J Szabó2, Magnus Schou5.   

Abstract

Nucleophilic 18F-fluorination of bromodifluoromethyl derivatives was performed using [18F]Bu4NF in the presence of DBU (1,8-diazabicyclo[5.4.0]undec-7-ene). This novel procedure provided a diverse set of [18F]trifluoroacetamides in good to excellent radiochemical conversions. A mechanism where DBU acts as organomediator in this transformation is proposed.

Entities:  

Year:  2016        PMID： 27844069     DOI： 10.1039/c6cc08535k

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  5 in total

1.  Quinuclidine and DABCO Enhance the Radiofluorinations of 5-Substituted 2-Halopyridines.

Authors:  Gregory R Naumiec; Lisheng Cai; Shuiyu Lu; Victor W Pike
Journal:  European J Org Chem       Date:  2017-09-04

2.  Radiosynthesis and evaluation of a fluorine-18 radiotracer [18F]FS1P1 for imaging sphingosine-1-phosphate receptor 1.

Authors:  Lin Qiu; Hao Jiang; Yanbo Yu; Jiwei Gu; Jinzhi Wang; Haiyang Zhao; Tianyu Huang; Robert J Gropler; Robyn S Klein; Joel S Perlmutter; Zhude Tu
Journal:  Org Biomol Chem       Date:  2022-02-02       Impact factor: 3.876

Review 3.  Advances in [18F]Trifluoromethylation Chemistry for PET Imaging.

Authors:  Felix Francis; Frank Wuest
Journal:  Molecules       Date:  2021-10-27       Impact factor: 4.411

4.  Synthesis of Fluorinated Alkyl Aryl Ethers by Palladium-Catalyzed C-O Cross-Coupling.

Authors:  Robert Szpera; Patrick G Isenegger; Maxime Ghosez; Natan J W Straathof; Rosa Cookson; David C Blakemore; Paul Richardson; Véronique Gouverneur
Journal:  Org Lett       Date:  2020-08-04       Impact factor: 6.005

Review 5.  Closing the gap between 19F and 18F chemistry.

Authors:  Javier Ajenjo; Gianluca Destro; Bart Cornelissen; Véronique Gouverneur
Journal:  EJNMMI Radiopharm Chem       Date:  2021-09-25
  5 in total

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