Young Jun Chai1, Jin Wook Yi2, So Won Oh3, Young A Kim4, Ka Hee Yi5, Ju Han Kim6, Kyu Eun Lee7. 1. Department of Surgery, Seoul National University Boramae Medical Center, Seoul, Korea; Cancer Research Institute, Seoul National University Hospital and College of Medicine, Seoul, Korea. 2. Cancer Research Institute, Seoul National University Hospital and College of Medicine, Seoul, Korea; Department of Surgery, Seoul National University Hospital and College of Medicine, Seoul, Korea. 3. Department of Nuclear Medicine, Seoul National University Boramae Medical Center, Seoul, Korea. 4. Department of Pathology, Seoul National University Boramae Medical Center, Seoul, Korea. 5. Department of Internal Medicine, Seoul National University Boramae Medical Center, Seoul, Korea. 6. Division of Biomedical Informatics, Systems Biomedical Informatics Research Center, Seoul National University College of Medicine, Seoul, Korea. 7. Cancer Research Institute, Seoul National University Hospital and College of Medicine, Seoul, Korea; Department of Surgery, Seoul National University Hospital and College of Medicine, Seoul, Korea. Electronic address: kyu.eun.lee.md@snu.ac.kr.
Abstract
BACKGROUND: The Warburg effect describes increased glucose uptake in cancer cells, and glucose transporter proteins are overexpressed in many tumors. In this study, we evaluated the expression of 14 SLC2A genes encoding glucose transporter proteins in papillary thyroid carcinoma patients. METHODS: Clinical information and gene expression data from 499 papillary thyroid carcinoma patients were downloaded from The Cancer Genome Atlas database. Correlations between SLC2 gene family (SLC2A1-14) mRNA expression levels and clinicopathologic factors were analyzed. RESULTS: There were 14 mortalities during follow-up (median, 21.6 months). Patient overall mortality was associated with age ≥45 years, extrathyroidal extension, higher TNM stage, and increased expression of SLC2A1, SLC2A3, and SLC2A14 mRNA. Greater SLC2A1, SLC2A3, and SLC2A14 expression was associated with increased mortality (odds ratio: 11.692, 95% confidence interval: 3.362-36.938; odds ratio: 12.725, 95% confidence interval: 4.247-40.187; and odds ratio: 13.768, 95% confidence interval: 4.208-61.710, respectively). Kaplan-Meier survival analysis indicated that overall survival was shorter in patients with high rather than low SCL2 expression (SLC2A1, P = .003; SLC2A3, P < .001; and SLC2A14, P < .001). CONCLUSION: Upregulation of the SLC2A1, SLC2A3, and SLC2A14 genes was associated with increased mortality in papillary thyroid carcinoma patients, and SLC2 gene expression levels are potentially useful prognostic indicators.
BACKGROUND: The Warburg effect describes increased glucose uptake in cancer cells, and glucose transporter proteins are overexpressed in many tumors. In this study, we evaluated the expression of 14 SLC2A genes encoding glucose transporter proteins in papillary thyroid carcinomapatients. METHODS: Clinical information and gene expression data from 499 papillary thyroid carcinomapatients were downloaded from The Cancer Genome Atlas database. Correlations between SLC2 gene family (SLC2A1-14) mRNA expression levels and clinicopathologic factors were analyzed. RESULTS: There were 14 mortalities during follow-up (median, 21.6 months). Patient overall mortality was associated with age ≥45 years, extrathyroidal extension, higher TNM stage, and increased expression of SLC2A1, SLC2A3, and SLC2A14 mRNA. Greater SLC2A1, SLC2A3, and SLC2A14 expression was associated with increased mortality (odds ratio: 11.692, 95% confidence interval: 3.362-36.938; odds ratio: 12.725, 95% confidence interval: 4.247-40.187; and odds ratio: 13.768, 95% confidence interval: 4.208-61.710, respectively). Kaplan-Meier survival analysis indicated that overall survival was shorter in patients with high rather than low SCL2 expression (SLC2A1, P = .003; SLC2A3, P < .001; and SLC2A14, P < .001). CONCLUSION: Upregulation of the SLC2A1, SLC2A3, and SLC2A14 genes was associated with increased mortality in papillary thyroid carcinomapatients, and SLC2 gene expression levels are potentially useful prognostic indicators.
Authors: Helen Wedegaertner; Wen-An Pan; Carlos C Gonzalez; David J Gonzalez; JoAnn Trejo Journal: Antioxid Redox Signal Date: 2022-01-04 Impact factor: 7.468
Authors: Andreas M Hoff; Sigrid M Kraggerud; Sharmini Alagaratnam; Kaja C G Berg; Bjarne Johannessen; Maren Høland; Gro Nilsen; Ole C Lingjærde; Peter W Andrews; Ragnhild A Lothe; Rolf I Skotheim Journal: Endocr Relat Cancer Date: 2020-09 Impact factor: 5.678