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Literature DB >> 27842775

Epidemiology and Genetic Risk Factors of Drug Hepatotoxicity.

Abstract

Idiosyncratic drug-induced liver injury (DILI) from prescription medications and herbal and dietary supplements has an annual incidence rate of approximately 20 cases per 100,000 per year. However, the risk of DILI varies greatly according to the drug. In the United States and Europe, antimicrobials are the commonest implicated agents, with amoxicillin/clavulanate the most common, whereas in Asian countries, herbal and dietary supplements predominate. Genetic analysis of DILI is currently limited, but multiple polymorphisms of human leukocyte antigen genes and genes involved in drug metabolism and transport have been identified as risk factors for DILI.

Entities: Chemical Disease Species

Keywords: Drug-induced liver injury (DILI); Epidemiology; Genetics

Mesh：

Substances：

Year: 2016 PMID： 27842775 PMCID： PMC8290403 DOI： 10.1016/j.cld.2016.08.004

Source DB: PubMed Journal: Clin Liver Dis ISSN： 1089-3261 Impact factor: 6.126

72 in total

Review 1. NAT2 polymorphisms and susceptibility to anti-tuberculosis drug-induced liver injury: a meta-analysis.

Authors: P-Y Wang; S-Y Xie; Q Hao; C Zhang; B-F Jiang
Journal: Int J Tuberc Lung Dis Date: 2012-03-08 Impact factor: 2.373

2. Ascertainment of acute liver injury in two European primary care databases.

Authors: A Ruigómez; R Brauer; L A García Rodríguez; C Huerta; G Requena; M Gil; Francisco de Abajo; G Downey; A Bate; M Feudjo Tepie; M de Groot; R Schlienger; R Reynolds; O Klungel
Journal: Eur J Clin Pharmacol Date: 2014-07-29 Impact factor: 2.953

3. Drug-induced liver injury in a Swedish University hospital out-patient hepatology clinic.

Authors: M B De Valle; V Av Klinteberg; N Alem; R Olsson; E Björnsson
Journal: Aliment Pharmacol Ther Date: 2006-10-15 Impact factor: 8.171

4. Evaluation of cases of severe statin-related transaminitis within a large health maintenance organization.

Authors: Evguenia C Charles; Kari L Olson; Brian G Sandhoff; David L McClure; John A Merenich
Journal: Am J Med Date: 2005-06 Impact factor: 4.965

5. Liver injury from herbals and dietary supplements in the U.S. Drug-Induced Liver Injury Network.

Authors: Victor J Navarro; Huiman Barnhart; Herbert L Bonkovsky; Timothy Davern; Robert J Fontana; Lafaine Grant; K Rajender Reddy; Leonard B Seeff; Jose Serrano; Averell H Sherker; Andrew Stolz; Jayant Talwalkar; Maricruz Vega; Raj Vuppalanchi
Journal: Hepatology Date: 2014-08-25 Impact factor: 17.425

6. Hepatotoxicity associated with nevirapine or efavirenz-containing antiretroviral therapy: role of hepatitis C and B infections.

Authors: Mark S Sulkowski; David L Thomas; Shruti H Mehta; Richard E Chaisson; Richard D Moore
Journal: Hepatology Date: 2002-01 Impact factor: 17.425

7. Lapatinib-induced liver injury characterized by class II HLA and Gilbert's syndrome genotypes.

Authors: C F Spraggs; L R Parham; C M Hunt; C T Dollery
Journal: Clin Pharmacol Ther Date: 2012-02-22 Impact factor: 6.875

8. Relationship between characteristics of medications and drug-induced liver disease phenotype and outcome.

Authors: Raj Vuppalanchi; Raghavender Gotur; K Rajender Reddy; Robert J Fontana; Marwan Ghabril; Andrzej S Kosinski; Jiezhun Gu; Jose Serrano; Naga Chalasani
Journal: Clin Gastroenterol Hepatol Date: 2013-12-20 Impact factor: 11.382

9. Limited contribution of common genetic variants to risk for liver injury due to a variety of drugs.

Authors: Thomas J Urban; Yufeng Shen; Andrew Stolz; Naga Chalasani; Robert J Fontana; James Rochon; Dongliang Ge; Kevin V Shianna; Ann K Daly; M Isabel Lucena; Matthew R Nelson; Mariam Molokhia; Guruprasad P Aithal; Aris Floratos; Itsik Pe'er; Jose Serrano; Herbert Bonkovsky; Timothy J Davern; William M Lee; Victor J Navarro; Jayant A Talwalkar; David B Goldstein; Paul B Watkins
Journal: Pharmacogenet Genomics Date: 2012-11 Impact factor: 2.089

10. Phenotypic characterization of idiosyncratic drug-induced liver injury: the influence of age and sex.

Authors: M Isabel Lucena; Raúl J Andrade; Neil Kaplowitz; Miren García-Cortes; M Carmen Fernández; Manuel Romero-Gomez; Miguel Bruguera; Hacibe Hallal; Mercedes Robles-Diaz; Jose F Rodriguez-González; Jose Maria Navarro; Javier Salmeron; Pedro Martinez-Odriozola; Ramón Pérez-Alvarez; Yolanda Borraz; Ramón Hidalgo
Journal: Hepatology Date: 2009-06 Impact factor: 17.425

9 in total

1. Liver Test Monitoring: Real-World Compliance for Drugs with Monitoring Requirements at 2-Week Intervals or More Frequently.

Authors: Marsha A Wilcox; Jill Hardin; James Weaver; Erica A Voss
Journal: Pharmaceut Med Date: 2019-10

Epidemiology and Genetic Risk Factors of Drug Hepatotoxicity.

Review 1. NAT2 polymorphisms and susceptibility to anti-tuberculosis drug-induced liver injury: a meta-analysis.

2. Ascertainment of acute liver injury in two European primary care databases.

3. Drug-induced liver injury in a Swedish University hospital out-patient hepatology clinic.

4. Evaluation of cases of severe statin-related transaminitis within a large health maintenance organization.

5. Liver injury from herbals and dietary supplements in the U.S. Drug-Induced Liver Injury Network.

6. Hepatotoxicity associated with nevirapine or efavirenz-containing antiretroviral therapy: role of hepatitis C and B infections.

7. Lapatinib-induced liver injury characterized by class II HLA and Gilbert's syndrome genotypes.

8. Relationship between characteristics of medications and drug-induced liver disease phenotype and outcome.

9. Limited contribution of common genetic variants to risk for liver injury due to a variety of drugs.

10. Phenotypic characterization of idiosyncratic drug-induced liver injury: the influence of age and sex.

1. Liver Test Monitoring: Real-World Compliance for Drugs with Monitoring Requirements at 2-Week Intervals or More Frequently.

Review 2. Roles of Cofactors in Drug-Induced Liver Injury: Drug Metabolism and Beyond.

3. Late-onset isavuconazole-induced liver injury.

4. Incidence, clinical features, and risk factors of fluoroquinolone-induced acute liver injury: a case-control study.

5. Drug induced liver injury is associated with high mortality-A study from a tertiary care hospital in Pakistan.

Review 6. A Critical Perspective on 3D Liver Models for Drug Metabolism and Toxicology Studies.

7. Liver Transplantation for Acute Liver Injury in Asians Is More Likely Due to Herbal and Dietary Supplements.

8. Glutamine powder-induced hepatotoxicity: it is time to understand the side effects of sports nutritional supplements.

Review 9. Antidepressants- and antipsychotics-induced hepatotoxicity.