Literature DB >> 27842772

Evolution of Experimental Models of the Liver to Predict Human Drug Hepatotoxicity and Efficacy.

Lawrence A Vernetti1, Andreas Vogt2, Albert Gough2, D Lansing Taylor3.   

Abstract

In this article, we review the past applications of in vitro models in identifying human hepatotoxins and then focus on the use of multiscale experimental models in drug development, including the use of zebrafish and human cell-based, 3-dimensional, microfluidic systems of liver functions as key components in applying Quantitative Systems Pharmacology (QSP). We have implemented QSP as a platform to improve the rate of success in the process of drug discovery and development of therapeutics.
Copyright © 2016 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Drug discovery; Drug-induced liver injury; Human liver models; In vitro hepatotoxicity; Liver toxicology; Microphysiology liver; Quantitative system pharmacology

Mesh：

Year:  2017        PMID： 27842772      PMCID： PMC6325638          DOI： 10.1016/j.cld.2016.08.013

Source DB:  PubMed          Journal:  Clin Liver Dis        ISSN： 1089-3261            Impact factor:   6.126


  9 in total

1.  A cell lines derived microfluidic liver model for investigation of hepatotoxicity induced by drug-drug interaction.

Authors:  Jiu Deng; Xiuli Zhang; Zongzheng Chen; Yong Luo; Yao Lu; Tingjiao Liu; Zhengzhi Wu; Yu Jin; Weijie Zhao; Bingcheng Lin
Journal:  Biomicrofluidics       Date:  2019-03-07       Impact factor: 2.800

2.  A glass-based, continuously zonated and vascularized human liver acinus microphysiological system (vLAMPS) designed for experimental modeling of diseases and ADME/TOX.

Authors:  Xiang Li; Subin M George; Lawrence Vernetti; Albert H Gough; D Lansing Taylor
Journal:  Lab Chip       Date:  2018-08-21       Impact factor: 6.799

Review 3.  Pre-clinical and clinical investigations of metabolic zonation in liver diseases: The potential of microphysiology systems.

Authors:  Alejandro Soto-Gutierrez; Albert Gough; Lawrence A Vernetti; D L Taylor; Satdarshan P Monga
Journal:  Exp Biol Med (Maywood)       Date:  2017-05-03

4.  Evaluation of Human Liver Microtissues for Drug Screening on Schistosoma mansoni Schistosomula.

Authors:  Flavio C Lombardo; Paolo S Ravaynia; Mario M Modena; Andreas Hierlemann; Jennifer Keiser
Journal:  ACS Infect Dis       Date:  2020-10-26       Impact factor: 5.084

Review 5.  Use of Zebrafish in Drug Discovery Toxicology.

Authors:  Steven Cassar; Isaac Adatto; Jennifer L Freeman; Joshua T Gamse; Iñaki Iturria; Christian Lawrence; Arantza Muriana; Randall T Peterson; Steven Van Cruchten; Leonard I Zon
Journal:  Chem Res Toxicol       Date:  2019-11-16       Impact factor: 3.739

Review 6.  Human biomimetic liver microphysiology systems in drug development and precision medicine.

Authors:  Albert Gough; Alejandro Soto-Gutierrez; Lawrence Vernetti; Mo R Ebrahimkhani; Andrew M Stern; D Lansing Taylor
Journal:  Nat Rev Gastroenterol Hepatol       Date:  2020-12-17       Impact factor: 73.082

7.  Improving natural product research translation: From source to clinical trial.

Authors:  Barbara C Sorkin; Adam J Kuszak; Gregory Bloss; Naomi K Fukagawa; Freddie Ann Hoffman; Mahtab Jafari; Bruce Barrett; Paula N Brown; Frederic D Bushman; Steven J Casper; Floyd H Chilton; Christopher S Coffey; Mario G Ferruzzi; D Craig Hopp; Mairead Kiely; Daniel Lakens; John B MacMillan; David O Meltzer; Marco Pahor; Jeffrey Paul; Kathleen Pritchett-Corning; Sara K Quinney; Barbara Rehermann; Kenneth D R Setchell; Nisha S Sipes; Jacqueline M Stephens; D Lansing Taylor; Hervé Tiriac; Michael A Walters; Dan Xi; Giovanna Zappalá; Guido F Pauli
Journal:  FASEB J       Date:  2019-12-10       Impact factor: 5.834

Review 8.  A Critical Perspective on 3D Liver Models for Drug Metabolism and Toxicology Studies.

Authors:  Ana S Serras; Joana S Rodrigues; Madalena Cipriano; Armanda V Rodrigues; Nuno G Oliveira; Joana P Miranda
Journal:  Front Cell Dev Biol       Date:  2021-02-22

9.  Liver Acinus Dynamic Chip for Assessment of Drug-Induced Zonal Hepatotoxicity.

Authors:  Dohyung Kwon; Geonho Choi; Song-A Park; Sungwoo Cho; Sihun Cho; Sungho Ko
Journal:  Biosensors (Basel)       Date:  2022-06-23
  9 in total

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