Literature DB >> 27842744

Ventilator-induced Lung Injury.

Jeremy R Beitler1, Atul Malhotra2, B Taylor Thompson3.   

Abstract

Prevention of ventilator-induced lung injury (VILI) can attenuate multiorgan failure and improve survival in at-risk patients. Clinically significant VILI occurs from volutrauma, barotrauma, atelectrauma, biotrauma, and shear strain. Differences in regional mechanics are important in VILI pathogenesis. Several interventions are available to protect against VILI. However, most patients at risk of lung injury do not develop VILI. VILI occurs most readily in patients with concomitant physiologic insults. VILI prevention strategies must balance risk of lung injury with untoward side effects from the preventive effort, and may be most effective when targeted to subsets of patients at increased risk.
Copyright © 2016 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Acute lung injury; Acute respiratory distress syndrome; Mechanical ventilation; Respiratory mechanics; Ventilator-induced lung injury

Mesh：

Year:  2016        PMID： 27842744      PMCID： PMC5131805          DOI： 10.1016/j.ccm.2016.07.004

Source DB:  PubMed          Journal:  Clin Chest Med        ISSN： 0272-5231            Impact factor:   2.878


  130 in total

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