Literature DB >> 27841590

Controlling segregation speed of entangled polymers by the shapes: A simple model for eukaryotic chromosome segregation.

Yuji Sakai1,2, Masashi Tachikawa2, Atsushi Mochizuki2.   

Abstract

We report molecular dynamics simulations of the segregation of two overlapping polymers motivated by chromosome segregation in biological cells. We investigate the relationship between polymer shapes and segregation dynamics and show that elongation and compaction make entangled polymers segregate rapidly. This result suggests that eukaryotic chromosomes take such a characteristic rod-shaped structure, which is induced by condensins, to achieve rapid segregation.

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Year:  2016        PMID: 27841590     DOI: 10.1103/PhysRevE.94.042403

Source DB:  PubMed          Journal:  Phys Rev E        ISSN: 2470-0045            Impact factor:   2.529


  2 in total

1.  Chromosome organization by one-sided and two-sided loop extrusion.

Authors:  Edward J Banigan; Aafke A van den Berg; Hugo B Brandão; John F Marko; Leonid A Mirny
Journal:  Elife       Date:  2020-04-06       Impact factor: 8.713

2.  Modeling the functions of condensin in chromosome shaping and segregation.

Authors:  Yuji Sakai; Atsushi Mochizuki; Kazuhisa Kinoshita; Tatsuya Hirano; Masashi Tachikawa
Journal:  PLoS Comput Biol       Date:  2018-06-18       Impact factor: 4.475

  2 in total

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