Literature DB >> 2784117

Topical treatment of severe corneal ulcers with cyclosporin A.

M Zierhut1, H J Thiel, E G Weidle, R Waetjen, U Pleyer.   

Abstract

Cyclosporin A eye drops were used on six patients to treat corneal ulcers associated with rheumatic diseases, oculomucocutaneous syndrome, and Sjögren's syndrome. Conjunctival excision was additionally carried out in two cases. All ulcers healed rapidly. The mechanism of ulcer formation involving T-lymphocytes is discussed.

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Year:  1989        PMID： 2784117     DOI： 10.1007/bf02169821

Source DB:  PubMed          Journal:  Graefes Arch Clin Exp Ophthalmol        ISSN： 0721-832X            Impact factor:   3.117


  45 in total

1.  [On-suturing of cornea as therapy for serious chronic corneal diseases (author's transl)].

Authors:  A Reuscher
Journal:  Klin Monbl Augenheilkd       Date:  1974-10       Impact factor: 0.700

2.  Combined cryoapplications and peritomy in Mooren's ulcer.

Authors:  E Aviel
Journal:  Br J Ophthalmol       Date:  1972-01       Impact factor: 4.638

3.  Hydrophilic contact lenses in corneal disease. I. Superficial, sterile, indolent ulcers.

Authors:  H M Leibowitz; P Rosenthal
Journal:  Arch Ophthalmol       Date:  1971-02

4.  Mooren's ulcer. Treatment by conjunctival excision.

Authors:  S I Brown
Journal:  Br J Ophthalmol       Date:  1975-11       Impact factor: 4.638

5.  Activated T lymphocytes produce a matrix-degrading heparan sulphate endoglycosidase.

Authors:  Y Naparstek; I R Cohen; Z Fuks; I Vlodavsky
Journal:  Nature       Date:  1984 Jul 19-25       Impact factor: 49.962

6.  Peripheral rheumatoid ulceration and evidence for conjunctival collagenase production.

Authors:  R A Eiferman; D J Carothers; J A Yankeelov
Journal:  Am J Ophthalmol       Date:  1979-05       Impact factor: 5.258

7.  Cyclosporin A: tissue levels following topical and systemic administration to rabbits.

Authors:  T A Bell; A G Hunnisett
Journal:  Br J Ophthalmol       Date:  1986-11       Impact factor: 4.638

8.  Cyclosporin A treatment in two cases of corneal peripheral melting syndrome.

Authors:  P J Kruit; A T van Balen; J S Stilma
Journal:  Doc Ophthalmol       Date:  1985-01-31       Impact factor: 2.379

9.  Cyclosporin A mediates immunosuppression of primary cytotoxic T cell responses by impairing the release of interleukin 1 and interleukin 2.

Authors:  D Bunjes; C Hardt; M Röllinghoff; H Wagner
Journal:  Eur J Immunol       Date:  1981-08       Impact factor: 5.532
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  5 in total

Review 1.  Topical ciclosporin in the treatment of ocular surface disorders.

Authors:  S Tatlipinar; E K Akpek
Journal:  Br J Ophthalmol       Date:  2005-10       Impact factor: 4.638

2.  Topical cyclosporin stimulates neovascularization in resolving sterile rheumatoid central corneal ulcers.

Authors:  J D Gottsch; E K Akpek
Journal:  Trans Am Ophthalmol Soc       Date:  2000

3.  Influence of topical cyclosporine A and dissolvent on corneal epithelium permeability of fluorescein.

Authors:  J M Benítez del Castillo; A Castillo; N Toledano; S Durán; C del Aguila; M Otero; J García-Sanchez
Journal:  Doc Ophthalmol       Date:  1995       Impact factor: 2.379

Review 4.  Peripheral Ulcerative Keratitis: A Review.

Authors:  Kiana Hassanpour; Reem H ElSheikh; Amir Arabi; Charles R Frank; Abdelrahman M Elhusseiny; Taher K Eleiwa; Shiva Arami; Ali R Djalilian; Ahmad Kheirkhah
Journal:  J Ophthalmic Vis Res       Date:  2022-04-29

Review 5.  Cyclosporin. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in immunoregulatory disorders.

Authors:  Diana Faulds; Karen L Goa; Paul Benfield
Journal:  Drugs       Date:  1993-06       Impact factor: 9.546
  5 in total

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