Faruk Ozkul1, Muhammmet Kasim Arik1, Halil Erbiş2, Alpaslan Akbaş3, Vural Taner Yilmaz4, Ahmet Barutcu5, Ibrahim Ali Osmanoğlu2, Hüseyin Kocak4. 1. a Department of General Surgery, Faculty of Medicine , Çanakkale Onsekiz Mart University , Çanakkale , Turkey. 2. b Department of General Surgery, School of Medicine , Akdeniz University , Antalya , Turkey. 3. c Department of Urology, Faculty of Medicine , Çanakkale Onsekiz Mart University , Çanakkale , Turkey. 4. d Department of Internal Medicine, Division of Nephrology, School of Medicine , Akdeniz University , Antalya , Turkey. 5. e Department of Cardiology, Faculty of Medicine , Çanakkale Onsekiz Mart University , Çanakkale , Turkey.
Abstract
PURPOSE: Mortality is a major problem in renal transplant patients, and appropriate preoperative evaluation is very important. We retrospectively reviewed the left ventricle ejection fraction (LVEF) of renal transplant patients. MATERIAL AND METHODS: The clinical records of 1763 patients who had preoperative LVEF results and who underwent renal transplantation at Akdeniz University Faculty of Medicine during the years 2004-2014 were studied. The LVEF limit was set at 55%. LVEF, age, gender, diabetes mellitus, hypertension, type of dialysis were assessed by linear multiple regression analysis on survival. RESULTS: There were a total of 1763 renal transplant patients. Those with LVEF of <55% were identified as having left ventricular dysfunction. The mean LVEF was 59.4 ± 9.1 in the 43 patients who died after renal transplantation, while it was 62.6 ± 7.4 in the survivors (p = 0.02). The mortality rate in the LVEF < 55% group was 6.8% (11/162 patients), while mortality in the LVEF ≥ 55% group was 2% (32/1601 patients, p < 0.001). LVEF was found to be the most powerful variable on survival by the linear multiple regression analysis, R2 = 0.05, p < 0.001. CONCLUSION: LVEF may predict mortality in renal transplant patients. LVEF is known to be lower in patients with high cardiac mortality, who may require greater modifications of the postoperative risks.
PURPOSE: Mortality is a major problem in renal transplant patients, and appropriate preoperative evaluation is very important. We retrospectively reviewed the left ventricle ejection fraction (LVEF) of renal transplant patients. MATERIAL AND METHODS: The clinical records of 1763 patients who had preoperative LVEF results and who underwent renal transplantation at Akdeniz University Faculty of Medicine during the years 2004-2014 were studied. The LVEF limit was set at 55%. LVEF, age, gender, diabetes mellitus, hypertension, type of dialysis were assessed by linear multiple regression analysis on survival. RESULTS: There were a total of 1763 renal transplant patients. Those with LVEF of <55% were identified as having left ventricular dysfunction. The mean LVEF was 59.4 ± 9.1 in the 43 patients who died after renal transplantation, while it was 62.6 ± 7.4 in the survivors (p = 0.02). The mortality rate in the LVEF < 55% group was 6.8% (11/162 patients), while mortality in the LVEF ≥ 55% group was 2% (32/1601 patients, p < 0.001). LVEF was found to be the most powerful variable on survival by the linear multiple regression analysis, R2 = 0.05, p < 0.001. CONCLUSION: LVEF may predict mortality in renal transplant patients. LVEF is known to be lower in patients with high cardiac mortality, who may require greater modifications of the postoperative risks.
Authors: Akhil Vaid; Joy J Jiang; Ashwin Sawant; Karandeep Singh; Patricia Kovatch; Alexander W Charney; David M Charytan; Jasmin Divers; Benjamin S Glicksberg; Lili Chan; Girish N Nadkarni Journal: Clin J Am Soc Nephrol Date: 2022-06-06 Impact factor: 10.614