Ali Firoozabadi1, Sepideh Kolouri2, Mohammad M Zarshenas3, Alireza Salehi2, Seyed Hamdollah Mosavat4, Seyed Ali Dastgheib5. 1. Research Center for Psychiatry and Behavioural Sciences, Department of Psychiatry, School of Medicine, Hafiz Hospital, Shiraz, University of Medical Sciences, Shiraz, Iran. 2. Research Center for Traditional Medicine and History of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran; Department of Traditional Persian Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. 3. Medicinal Plants Processing Research Center, Shiraz University of Medical Sciences, Shiraz, Iran; Department of Phytopharmaceuticals (Traditional Pharmacy), School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran. 4. Research Center for Traditional Medicine and History of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. 5. Substance Abuse Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Abstract
BACKGROUND: The efficacy and safety of Nepeta menthoides freeze-dried aqueous extract were assessed on the anxiety of patients suffering from depression. METHOD: Patients received either N. menthoides formulation (400 mg/BID) or Sertraline (50 mg/BID) for 4 weeks. The Beck Anxiety Inventory (BAI) scales were used to assess the anxiety in two-week intervals (2nd, 4th, and 6th weeks). Folin-Ciocalteu and Dowd methods were used to determine the formulation of total phenol and flavonoid contents. RESULTS: Compared with Sertraline, N. menthoides showed a higher reduction in BAI scores in the 2nd (16.52±8.07 vs. 21.38±10.98, P<0.05) and 4th week (11.55±6.74 vs. 20.47±11.53, P<0.05) along with a reduction in the recurrence rate and side effects. Total phenolic and flavonoid contents revealed in the presence of 127.09±0.43 mg GAE/g and 16.93±0.09 mg Q/g of extract. CONCLUSION: N. menthoides could be effective in the control and introducing a delay in recurrence of anxiety in patients with depression.
RCT Entities:
BACKGROUND: The efficacy and safety of Nepeta menthoides freeze-dried aqueous extract were assessed on the anxiety of patients suffering from depression. METHOD:Patients received either N. menthoides formulation (400 mg/BID) or Sertraline (50 mg/BID) for 4 weeks. The Beck Anxiety Inventory (BAI) scales were used to assess the anxiety in two-week intervals (2nd, 4th, and 6th weeks). Folin-Ciocalteu and Dowd methods were used to determine the formulation of total phenol and flavonoid contents. RESULTS: Compared with Sertraline, N. menthoides showed a higher reduction in BAI scores in the 2nd (16.52±8.07 vs. 21.38±10.98, P<0.05) and 4th week (11.55±6.74 vs. 20.47±11.53, P<0.05) along with a reduction in the recurrence rate and side effects. Total phenolic and flavonoid contents revealed in the presence of 127.09±0.43 mg GAE/g and 16.93±0.09 mg Q/g of extract. CONCLUSION:N. menthoides could be effective in the control and introducing a delay in recurrence of anxiety in patients with depression.
Entities:
Keywords:
Anxiety; Depression; Herbal medicine; Medicine; Traditional
Authors: Maryam Ranjbar; Ali Firoozabadi; Alireza Salehi; Zahra Ghorbanifar; Mohammad M Zarshenas; Khosro Sadeghniiat-Haghighi; Hossein Rezaeizadeh Journal: Integr Med Res Date: 2018-08-10