OBJECTIVE: To identify the combined effect of prenatal and postnatal vitamin D3 supplementation on the vitamin D status of pregnant and lactating women and their exclusively breastfed infants. DESIGN: Double-blind, randomized controlled trial. SETTING:Upper Midwestern U.S., hospital-based obstetric practice. PARTICIPANTS: Pregnant women (N = 13) planning to exclusively breastfeed were randomized at 24 to 28 weeks gestation to receive vitamin D3 at a dosage of 400 IU (control group, n = 6) or 3,800 IU (intervention group, n = 7) daily through 4 to 6 weeks postpartum. Vitamin D status was determined at enrollment and in mother-infant dyads at 24 to 72 hours after birth and 4 to 6 weeks postpartum. METHODS:Serum 25-hydroxyvitamin D levels were measured to determine the effect of vitamin D3 supplementation on the vitamin D status of mothers and infants. Analysis of covariance was used to compare differences in 25-hydroxyvitamin D levels between the control and intervention groups. RESULTS: The mothers' vitamin D levels were significantly higher in the intervention group than in the control group at birth (p = .044) and at 4 to 6 weeks postpartum (p = .002). Infants in the intervention group had significantly higher vitamin D levels at birth (p = .021) and nonsignificant, clinically relevant increases at 4 to 6 weeks of age (p = .256). No differences were found between maternal groups in serum calcium or parathyroid hormone levels. CONCLUSION: Prenatal to postpartum vitamin D3 supplementation is an effective intervention to increase a mother's vitamin D status and to promote optimal vitamin D status in newborns and exclusively breastfed infants.
RCT Entities:
OBJECTIVE: To identify the combined effect of prenatal and postnatal vitamin D3 supplementation on the vitamin D status of pregnant and lactating women and their exclusively breastfed infants. DESIGN: Double-blind, randomized controlled trial. SETTING: Upper Midwestern U.S., hospital-based obstetric practice. PARTICIPANTS: Pregnant women (N = 13) planning to exclusively breastfeed were randomized at 24 to 28 weeks gestation to receive vitamin D3 at a dosage of 400 IU (control group, n = 6) or 3,800 IU (intervention group, n = 7) daily through 4 to 6 weeks postpartum. Vitamin D status was determined at enrollment and in mother-infant dyads at 24 to 72 hours after birth and 4 to 6 weeks postpartum. METHODS: Serum 25-hydroxyvitamin D levels were measured to determine the effect of vitamin D3 supplementation on the vitamin D status of mothers and infants. Analysis of covariance was used to compare differences in 25-hydroxyvitamin D levels between the control and intervention groups. RESULTS: The mothers' vitamin D levels were significantly higher in the intervention group than in the control group at birth (p = .044) and at 4 to 6 weeks postpartum (p = .002). Infants in the intervention group had significantly higher vitamin D levels at birth (p = .021) and nonsignificant, clinically relevant increases at 4 to 6 weeks of age (p = .256). No differences were found between maternal groups in serum calcium or parathyroid hormone levels. CONCLUSION: Prenatal to postpartum vitamin D3 supplementation is an effective intervention to increase a mother's vitamin D status and to promote optimal vitamin D status in newborns and exclusively breastfed infants.
Authors: Karen M O'Callaghan; Mahgol Taghivand; Anna Zuchniak; Akpevwe Onoyovwi; Jill Korsiak; Michael Leung; Daniel E Roth Journal: Adv Nutr Date: 2020-01-01 Impact factor: 8.701
Authors: Cindy M Anderson; Shannon L Gillespie; Doria K Thiele; Jody L Ralph; Joyce E Ohm Journal: Breastfeed Med Date: 2018-05-21 Impact factor: 1.817
Authors: Carol L Wagner; Thomas C Hulsey; Myla Ebeling; Judy R Shary; Golaleh Asghari; Cynthia R Howard; John E Baatz; Danforth A Newton; Amy E Wahlquist; Susan G Reed; Sarah N Taylor; Ruth A Lawrence; Bruce W Hollis Journal: Breastfeed Med Date: 2020-09-11 Impact factor: 1.817
Authors: Cristina Palacios; Maria Angelica Trak-Fellermeier; Ricardo X Martinez; Lucero Lopez-Perez; Paul Lips; James A Salisi; Jessica C John; Juan Pablo Peña-Rosas Journal: Cochrane Database Syst Rev Date: 2019-10-03