Literature DB >> 27840151

CD98 signals controlling tumorigenesis.

Hugh Ip1, Tariq Sethi2.   

Abstract

CD98 is implicated in a large number of cancers. CD98 regulates amino acid transport and integrin signaling, which are key drivers in tumor progression. The light chain in the CD98 heterodimer functions as an amino acid exchanger. Alongside the light chain, the heavy chain forms a heterocomplex at the plasma membrane to mediate signaling pathways. In this article, we review various approaches to blocking CD98 activity, which may lead to novel opportunities in cancer therapeutics.
Copyright © 2016 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Amino acid transport; CD98;Cancer; Integrins; Signalling

Mesh：

Substances：

Year:  2016        PMID： 27840151     DOI： 10.1016/j.biocel.2016.11.005

Source DB:  PubMed          Journal:  Int J Biochem Cell Biol        ISSN： 1357-2725            Impact factor:   5.085


  7 in total

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Journal:  Immunology       Date:  2018-03-07       Impact factor: 7.397

2.  A novel anti-c-Kit antibody-drug conjugate to treat wild-type and activating-mutant c-Kit-positive tumors.

Authors:  Jin-Ock Kim; Kwang-Hyeok Kim; Eun Ji Baek; Bomi Park; Min Kyung So; Byoung Joon Ko; Han-Jik Ko; Sang Gyu Park
Journal:  Mol Oncol       Date:  2021-08-29       Impact factor: 6.603

3.  Specificities of exosome versus small ectosome secretion revealed by live intracellular tracking of CD63 and CD9.

Authors:  Mathilde Mathieu; Nathalie Névo; Mabel Jouve; José Ignacio Valenzuela; Mathieu Maurin; Frederik J Verweij; Roberta Palmulli; Danielle Lankar; Florent Dingli; Damarys Loew; Eric Rubinstein; Gaëlle Boncompain; Franck Perez; Clotilde Théry
Journal:  Nat Commun       Date:  2021-07-19       Impact factor: 14.919

4.  N-glycosylation is crucial for trafficking and stability of SLC3A2 (CD98).

Authors:  Lara Console; Mariafrancesca Scalise; Simona Salerno; Raffaella Scanga; Deborah Giudice; Loredana De Bartolo; Annamaria Tonazzi; Cesare Indiveri
Journal:  Sci Rep       Date:  2022-08-26       Impact factor: 4.996

5.  Hepatitis C Virus Modulates Solute carrier family 3 member 2 for Viral Propagation.

Authors:  Ngan N T Nguyen; Yun-Sook Lim; Lap P Nguyen; Si C Tran; Trang T D Luong; Tram T T Nguyen; Hang T Pham; Han N Mai; Jae-Woong Choi; Sang-Seop Han; Soon B Hwang
Journal:  Sci Rep       Date:  2018-10-19       Impact factor: 4.379

Review 6.  The Regulation and Function of the L-Type Amino Acid Transporter 1 (LAT1) in Cancer.

Authors:  Travis B Salisbury; Subha Arthur
Journal:  Int J Mol Sci       Date:  2018-08-12       Impact factor: 5.923

7.  Myeloid deletion of phosphoinositide-dependent kinase-1 enhances NK cell-mediated antitumor immunity by mediating macrophage polarization.

Authors:  Yuexi He; Juan Du; Zhongjun Dong
Journal:  Oncoimmunology       Date:  2020-06-03       Impact factor: 8.110
  7 in total

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