Athanasios Chalkias1, Fotios Pavlopoulos2, Anastasios Koutsovasilis3, Ernesto d'Aloja4, Theodoros Xanthos5. 1. National and Kapodistrian University of Athens, Medical School, M.Sc. "Cardiopulmonary Resuscitation", Athens, Greece; Hellenic Society of Cardiopulmonary Resuscitation, Athens, Greece; Tzaneio General Hospital, Department of Anesthesiology, Piraeus, Greece. Electronic address: thanoschalkias@yahoo.gr. 2. Tzaneio General Hospital, Department of Anesthesiology, Piraeus, Greece. 3. Nikaia General Hospital, 3rd Department of Internal Medicine, Piraeus, Greece. 4. University of Cagliari, Department of Public Health, Clinical and Molecular Medicine, Cagliari, Italy. 5. Hellenic Society of Cardiopulmonary Resuscitation, Athens, Greece; European University Cyprus, School of Medicine, Nicosia, Cyprus.
Abstract
AIM: To assess the usefulness of airway pressure as predictor of return of spontaneous circulation (ROSC), as well as to investigate the optimized ventilation compression strategy during cardiopulmonary resuscitation (CPR). METHODS: In this prospective observational study, 300 out-of-hospital cardiac arrest victims were intubated and resuscitated with the use of a ventilator. Mean airway pressure (mPaw) was measured at pre-defined phases of CPR. RESULTS: A significant difference in mPaw was observed between survivors and non-survivors after the onset of the third minute of CPR. An mPaw value of 42.5mbar during CPR had specificity and sensitivity of 0.788 and 0.804, respectively, for ROSC (AUC=0.668, p=0.047). During CPR, we found statistically significant differences in mPaw at phases zero (F=4.526, p=0.002), two (F=4.506, p=0.002), four (F=8.187, p<0.0001), five (F=2.871, p=0.024), and six (F=5.364, p<0.0001). CONCLUSION: Mean airway pressure was higher in survivors. A value of 42.5mbar was associated with ROSC.
AIM: To assess the usefulness of airway pressure as predictor of return of spontaneous circulation (ROSC), as well as to investigate the optimized ventilation compression strategy during cardiopulmonary resuscitation (CPR). METHODS: In this prospective observational study, 300 out-of-hospital cardiac arrest victims were intubated and resuscitated with the use of a ventilator. Mean airway pressure (mPaw) was measured at pre-defined phases of CPR. RESULTS: A significant difference in mPaw was observed between survivors and non-survivors after the onset of the third minute of CPR. An mPaw value of 42.5mbar during CPR had specificity and sensitivity of 0.788 and 0.804, respectively, for ROSC (AUC=0.668, p=0.047). During CPR, we found statistically significant differences in mPaw at phases zero (F=4.526, p=0.002), two (F=4.506, p=0.002), four (F=8.187, p<0.0001), five (F=2.871, p=0.024), and six (F=5.364, p<0.0001). CONCLUSION: Mean airway pressure was higher in survivors. A value of 42.5mbar was associated with ROSC.