Jiayu Peng1, Ying Huang2. 1. Department of Respiratory Medicine, Children's Hospital of Chongqing Medical University, Chongqing, China. 2. Department of Respiratory Medicine, Children's Hospital of Chongqing Medical University, Chongqing, China. Electronic address: huangying126163@126.com.
Abstract
BACKGROUND: The reported associations of blood lipid profiles with asthma are ambiguous. OBJECTIVE: To explore the association between asthma and the serum levels of high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C). METHODS: A systematic search was performed in the PubMed, MEDLINE, Cochrane Library, and Chinese Biomedical Literature databases. Ten studies were identified. We divided these studies into 2 subgroups according to age: children (<18 years old) and adults (≥18 years old). RESULTS: In children, the asthma group had lower HDL-C levels (weighted mean difference, -3.44; 95% confidence interval [CI], -5.83 to -1.04; P = .005) compared with the nonasthma group, whereas the serum levels of LDL-C in these 2 groups were not statistically different. In contrary, in adults, the asthma group had higher LDL-C levels (weighted mean difference, 8.95; 95% confidence interval, 3.55-14.35; P = .001) compared with the nonasthma group, whereas the HDL-C levels were not statistically different. CONCLUSION: There is a significant association between asthma and the serum levels of HDL-C and LDL-C. Moreover, this association differs in children and adults.
BACKGROUND: The reported associations of blood lipid profiles with asthma are ambiguous. OBJECTIVE: To explore the association between asthma and the serum levels of high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C). METHODS: A systematic search was performed in the PubMed, MEDLINE, Cochrane Library, and Chinese Biomedical Literature databases. Ten studies were identified. We divided these studies into 2 subgroups according to age: children (<18 years old) and adults (≥18 years old). RESULTS: In children, the asthma group had lower HDL-C levels (weighted mean difference, -3.44; 95% confidence interval [CI], -5.83 to -1.04; P = .005) compared with the nonasthma group, whereas the serum levels of LDL-C in these 2 groups were not statistically different. In contrary, in adults, the asthma group had higher LDL-C levels (weighted mean difference, 8.95; 95% confidence interval, 3.55-14.35; P = .001) compared with the nonasthma group, whereas the HDL-C levels were not statistically different. CONCLUSION: There is a significant association between asthma and the serum levels of HDL-C and LDL-C. Moreover, this association differs in children and adults.