Literature DB >> 27838899

CCN3: stopping that achy, breaky aorta.

Andrew Leask1.   

Abstract

Abdominal aortic aneurysm (AAA) affects between 2 and 8 % of males over the age of 65. Mortality if ruptured is 85 to 90 %, Recent data by Zhang and colleagues (J Clin Invest 126(4):1282-1299 2016) suggest that CCN3 might be used to treat AAA. This Bits and Bytes summarizes these findings.

Entities:  

Keywords:  Abdominal aortic aneurysm; CCN family; CCN3; Cardiovascular disease; Matricellular proteins; Nov

Year:  2016        PMID： 27838899      PMCID： PMC5362575          DOI： 10.1007/s12079-016-0363-5

Source DB:  PubMed          Journal:  J Cell Commun Signal        ISSN： 1873-9601            Impact factor:   5.782


  7 in total

1.  Nov gene encodes adhesion factor for vascular smooth muscle cells and is dynamically regulated in response to vascular injury.

Authors:  P D Ellis; Q Chen; P J Barker; J C Metcalfe; P R Kemp
Journal:  Arterioscler Thromb Vasc Biol       Date:  2000-08       Impact factor: 8.311

Review 2.  Taking aim at the extracellular matrix: CCN proteins as emerging therapeutic targets.

Authors:  Joon-Il Jun; Lester F Lau
Journal:  Nat Rev Drug Discov       Date:  2011-12-01       Impact factor: 84.694

3.  Thrombus within an aortic aneurysm does not reduce pressure on the aneurysmal wall.

Authors:  G W Schurink; J M van Baalen; M J Visser; J H van Bockel
Journal:  J Vasc Surg       Date:  2000-03       Impact factor: 4.268

Review 4.  Vascular wall extracellular matrix proteins and vascular diseases.

Authors:  Junyan Xu; Guo-Ping Shi
Journal:  Biochim Biophys Acta       Date:  2014-07-18

5.  A novel role of CCN3 in regulating endothelial inflammation.

Authors:  Zhiyong Lin; Viswanath Natesan; Hong Shi; Anne Hamik; Daiji Kawanami; Caili Hao; Ganapati H Mahabaleshwar; Weiye Wang; Zheng-Gen Jin; G Brandon Atkins; Sue M Firth; Laure Rittié; Bernard Perbal; Mukesh K Jain
Journal:  J Cell Commun Signal       Date:  2010-08-11       Impact factor: 5.782

6.  Matricellular protein CCN3 mitigates abdominal aortic aneurysm.

Authors:  Chao Zhang; Dustin van der Voort; Hong Shi; Rongli Zhang; Yulan Qing; Shuichi Hiraoka; Minoru Takemoto; Koutaro Yokote; Joseph V Moxon; Paul Norman; Laure Rittié; Helena Kuivaniemi; G Brandon Atkins; Stanton L Gerson; Guo-Ping Shi; Jonathan Golledge; Nianguo Dong; Bernard Perbal; Domenick A Prosdocimo; Zhiyong Lin
Journal:  J Clin Invest       Date:  2016-03-14       Impact factor: 14.808

Review 7.  Pathophysiology of abdominal aortic aneurysm relevant to improvements in patients' management.

Authors:  Jonathan Golledge; Paul E Norman
Journal:  Curr Opin Cardiol       Date:  2009-11       Impact factor: 2.161
  7 in total

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