OBJECTIVE: Preterm infants are at high risk for developmental delay, epilepsy, and autism spectrum disorders. Some reports have described associations between these conditions and gamma-aminobutyric acid (GABA) dysfunction; however, no study has evaluated temporal changes in GABA in preterm infants. Therefore, we assessed temporal changes in brain metabolites including GABA using single-voxel 3-Tesla (T) proton magnetic resonance spectroscopy (1H-MRS) in preterm infants with normal development. METHODS: We performed 3T 1H-MRS at 37-46 postmenstrual weeks (PMWs, period A) and 64-73PMWs (period B). GABA was assessed with the MEGA-PRESS method. N-acetyl aspartate (NAA), glutamate-glutamine complex (Glx), creatine (Cr), choline (Cho), and myo-inositol (Ins) were assessed with the PRESS method. Metabolite concentrations were automatically calculated using LCModel. RESULTS: Data were collected from 20 preterm infants for periods A and B (medians [ranges], 30 [24-34] gestational weeks, 1281 [486-2030]g birth weight). GABA/Cr ratio decreased significantly in period B (p=0.03), but there was no significant difference in GABA/Cho ratios (p=0.58) between the two periods. In period B, NAA/Cr, Glx/Cr, NAA/Cho, and Glx/Cho ratios were significantly increased (p<0.01), whereas Cho/Cr, Ins/Cr, and Ins/Cho ratios were significantly decreased (p<0.01). There was no significant difference for GABA or Cho concentrations (p=0.52, p=0.22, respectively). NAA, Glx, and Cr concentrations were significantly increased (p<0.01), whereas Ins was significantly decreased (p<0.01). CONCLUSIONS: Our results provide new information on normative values of brain metabolites in preterm infants.
OBJECTIVE: Preterm infants are at high risk for developmental delay, epilepsy, and autism spectrum disorders. Some reports have described associations between these conditions and gamma-aminobutyric acid (GABA) dysfunction; however, no study has evaluated temporal changes in GABA in preterm infants. Therefore, we assessed temporal changes in brain metabolites including GABA using single-voxel 3-Tesla (T) proton magnetic resonance spectroscopy (1H-MRS) in preterm infants with normal development. METHODS: We performed 3T 1H-MRS at 37-46 postmenstrual weeks (PMWs, period A) and 64-73PMWs (period B). GABA was assessed with the MEGA-PRESS method. N-acetyl aspartate (NAA), glutamate-glutamine complex (Glx), creatine (Cr), choline (Cho), and myo-inositol (Ins) were assessed with the PRESS method. Metabolite concentrations were automatically calculated using LCModel. RESULTS: Data were collected from 20 preterm infants for periods A and B (medians [ranges], 30 [24-34] gestational weeks, 1281 [486-2030]g birth weight). GABA/Cr ratio decreased significantly in period B (p=0.03), but there was no significant difference in GABA/Cho ratios (p=0.58) between the two periods. In period B, NAA/Cr, Glx/Cr, NAA/Cho, and Glx/Cho ratios were significantly increased (p<0.01), whereas Cho/Cr, Ins/Cr, and Ins/Cho ratios were significantly decreased (p<0.01). There was no significant difference for GABA or Cho concentrations (p=0.52, p=0.22, respectively). NAA, Glx, and Cr concentrations were significantly increased (p<0.01), whereas Ins was significantly decreased (p<0.01). CONCLUSIONS: Our results provide new information on normative values of brain metabolites in preterm infants.
Authors: S K Basu; S Pradhan; S D Barnett; M Mikkelsen; K J Kapse; J Murnick; J L Quistorff; C A Lopez; A J du Plessis; C Limperopoulos Journal: AJNR Am J Neuroradiol Date: 2021-11-11 Impact factor: 3.825
Authors: Yulu Song; Peter J Lally; Maria Yanez Lopez; Georg Oeltzschner; Mary Beth Nebel; Borjan Gagoski; Steven Kecskemeti; Steve C N Hui; Helge J Zöllner; Deepika Shukla; Tomoki Arichi; Enrico De Vita; Vivek Yedavalli; Sudhin Thayyil; Daniele Fallin; Douglas C Dean; P Ellen Grant; Jessica L Wisnowski; Richard A E Edden Journal: Neuroradiology Date: 2021-10-15 Impact factor: 2.995
Authors: Burcu Cebeci; Thomas Alderliesten; Jannie P Wijnen; Niek E van der Aa; Manon J N L Benders; Linda S de Vries; Agnes van den Hoogen; Floris Groenendaal Journal: Pediatr Res Date: 2021-05-05 Impact factor: 3.953
Authors: H G Moss; L G Wolf; P Coker-Bolt; V Ramakrishnan; T Aljuhani; M Yazdani; T R Brown; J H Jensen; D D Jenkins Journal: AJNR Am J Neuroradiol Date: 2021-12-23 Impact factor: 4.966
Authors: Yanez Lopez Maria; Anthony N Price; Nicolaas A J Puts; Emer J Hughes; Richard A E Edden; Grainne M McAlonan; Tomoki Arichi; Enrico De Vita Journal: Neuroimage Date: 2021-03-09 Impact factor: 6.556