Literature DB >> 2783775

The PreA4(695) precursor protein of Alzheimer's disease A4 amyloid is encoded by 16 exons.

H G Lemaire1, J M Salbaum, G Multhaup, J Kang, R M Bayney, A Unterbeck, K Beyreuther, B Müller-Hill.   

Abstract

Alzheimer's disease (AD) is characterized by the cerebral deposition of fibrillar aggregates of the amyloid A4 protein. Complementary DNA's coding for the precursor of the amyloid A4 protein have been described. In order to identify the structure of the precursor gene relevant clones from several human genomic libraries were isolated. Sequence analysis of the various clones revealed 16 exons to encode the 695 residue precursor protein (PreA4(695] of Alzheimer's disease amyloid A4 protein. The DNA sequence coding for the amyloid A4 protein is interrupted by an intron. This finding supports the idea that amyloid A4 protein arises by incomplete proteolysis of a larger precursor, and not by aberrant splicing.

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Year:  1989        PMID： 2783775      PMCID： PMC331600          DOI： 10.1093/nar/17.2.517

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  21 in total

1.  Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase.

Authors:  R K Saiki; D H Gelfand; S Stoffel; S J Scharf; R Higuchi; G T Horn; K B Mullis; H A Erlich
Journal:  Science       Date:  1988-01-29       Impact factor: 47.728

2.  Amyloid beta protein precursor is possibly a heparan sulfate proteoglycan core protein.

Authors:  D Schubert; R Schroeder; M LaCorbiere; T Saitoh; G Cole
Journal:  Science       Date:  1988-07-08       Impact factor: 47.728

3.  Novel precursor of Alzheimer's disease amyloid protein shows protease inhibitory activity.

Authors:  N Kitaguchi; Y Takahashi; Y Tokushima; S Shiojiri; H Ito
Journal:  Nature       Date:  1988-02-11       Impact factor: 49.962

4.  The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor.

Authors:  J Kang; H G Lemaire; A Unterbeck; J M Salbaum; C L Masters; K H Grzeschik; G Multhaup; K Beyreuther; B Müller-Hill
Journal:  Nature       Date:  1987 Feb 19-25       Impact factor: 49.962

Review 5.  Alzheimer's disease.

Authors:  R Katzman
Journal:  N Engl J Med       Date:  1986-04-10       Impact factor: 91.245

6.  A cDNA specifying the human amyloid beta precursor protein (ABPP) encodes a 95-kDa polypeptide.

Authors:  S Mita; J Sadlock; J Herbert; E A Schon
Journal:  Nucleic Acids Res       Date:  1988-10-11       Impact factor: 16.971

7.  Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease.

Authors:  R E Tanzi; A I McClatchey; E D Lamperti; L Villa-Komaroff; J F Gusella; R L Neve
Journal:  Nature       Date:  1988-02-11       Impact factor: 49.962

8.  A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors.

Authors:  P Ponte; P Gonzalez-DeWhitt; J Schilling; J Miller; D Hsu; B Greenberg; K Davis; W Wallace; I Lieberburg; F Fuller
Journal:  Nature       Date:  1988-02-11       Impact factor: 49.962

9.  Identification, transmembrane orientation and biogenesis of the amyloid A4 precursor of Alzheimer's disease.

Authors:  T Dyrks; A Weidemann; G Multhaup; J M Salbaum; H G Lemaire; J Kang; B Müller-Hill; C L Masters; K Beyreuther
Journal:  EMBO J       Date:  1988-04       Impact factor: 11.598

10.  Transfer of proteins across membranes. II. Reconstitution of functional rough microsomes from heterologous components.

Authors:  G Blobel; B Dobberstein
Journal:  J Cell Biol       Date:  1975-12       Impact factor: 10.539
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  22 in total

1.  Epitope map of two polyclonal antibodies that recognize amyloid lesions in patients with Alzheimer's disease.

Authors:  J Ghiso; T Wisniewski; R Vidal; A Rostagno; B Frangione
Journal:  Biochem J       Date:  1992-03-01       Impact factor: 3.857

2.  Interleukin-1 stimulates the beta-amyloid precursor protein promoter.

Authors:  R J Donnelly; A J Friedhoff; B Beer; A J Blume; M P Vitek
Journal:  Cell Mol Neurobiol       Date:  1990-12       Impact factor: 5.046

3.  Alzheimer amyloid beta-protein precursor in sperm development.

Authors:  M Shoji; T Kawarabayashi; Y Harigaya; H Yamaguchi; S Hirai; T Kamimura; T Sugiyama
Journal:  Am J Pathol       Date:  1990-11       Impact factor: 4.307

4.  Assessment of amyloid beta-protein precursor gene mutations in a large set of familial and sporadic Alzheimer disease cases.

Authors:  R E Tanzi; G Vaula; D M Romano; M Mortilla; T L Huang; R G Tupler; W Wasco; B T Hyman; J L Haines; B J Jenkins
Journal:  Am J Hum Genet       Date:  1992-08       Impact factor: 11.025

Review 5.  Genetics of Alzheimer disease.

Authors:  Lynn M Bekris; Chang-En Yu; Thomas D Bird; Debby W Tsuang
Journal:  J Geriatr Psychiatry Neurol       Date:  2010-12       Impact factor: 2.680

6.  Ribozyme mediated degradation of beta-amyloid peptide precursor mRNA in COS-7 cells.

Authors:  R B Denman; M Smedman; W Ju; R Rubenstein; A Potempska; D L Miller
Journal:  Nucleic Acids Res       Date:  1994-06-25       Impact factor: 16.971

Review 7.  Protein phosphorylation and APP metabolism.

Authors:  Edgar F da Cruz e Silva; Odete A B da Cruz e Silva
Journal:  Neurochem Res       Date:  2003-10       Impact factor: 3.996

8.  Identification of a stable fragment of the Alzheimer amyloid precursor containing the beta-protein in brain microvessels.

Authors:  A Tamaoka; R N Kalaria; I Lieberburg; D J Selkoe
Journal:  Proc Natl Acad Sci U S A       Date:  1992-02-15       Impact factor: 11.205

Review 9.  Lineage plasticity in cancer: a shared pathway of therapeutic resistance.

Authors:  Álvaro Quintanal-Villalonga; Joseph M Chan; Helena A Yu; Dana Pe'er; Charles L Sawyers; Triparna Sen; Charles M Rudin
Journal:  Nat Rev Clin Oncol       Date:  2020-03-09       Impact factor: 66.675

10.  A 109-amino-acid C-terminal fragment of Alzheimer's-disease amyloid precursor protein contains a sequence, -RHDS-, that promotes cell adhesion.

Authors:  J Ghiso; A Rostagno; J E Gardella; L Liem; P D Gorevic; B Frangione
Journal:  Biochem J       Date:  1992-12-15       Impact factor: 3.857
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