| Literature DB >> 27837682 |
Qiuming Liu1, Liwen Song2, Shuai Chen3, Jingyi Gao3, Peiyu Zhao2, Jianzhong Du4.
Abstract
Improving the relaxivity of magnetic resonance imaging (MRI) contrast agents is an important challenge for cancer theranostics. Herein we report the design, synthesis, characterization, theoretical analysis and in vivo tests of a superparamagnetic polymersome as a new MRI contrast agent with extremely high T2 relaxivity (611.6 mM-1s-1). First, a noncytotoxic cancer-targeting polymersome is synthesized based on a biodegradable diblock copolymer, folic acid-poly(l-glutamic acid)-block-poly(ε-caprolactone) [FA-PGA-b-PCL]. Then, ultra-small superparamagnetic iron oxide nanoparticles (SPIONs) are in situ generated in the hydrophilic PGA coronas of polymersomes to afford magnetic polymersomes. The in vivo MRI assay revealed prominent negative contrast enhancement of magnetic polymersomes at a very low Fe dose of 0.011 mmol/kg. Moreover, this cancer-targeting magnetic polymersome can effectively encapsulate and deliver anticancer drug to inhibit the tumor growth, demonstrating promising theranostic applications in biomedicine. Copyright ÂEntities:
Keywords: Antitumor drug delivery; MRI; Polymer vesicle; Polymersome; Self-assembly; Superparamagnetic iron oxide nanoparticles
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Year: 2016 PMID： 27837682 DOI： 10.1016/j.biomaterials.2016.10.027
Source DB: PubMed Journal: Biomaterials ISSN： 0142-9612 Impact factor: 12.479