Literature DB >> 27837413

Machine perfusion versus cold storage of livers: a meta-analysis.

Sushun Liu1, Qing Pang1, Jingyao Zhang1, Mimi Zhai1, Sinan Liu1, Chang Liu2.   

Abstract

Different organ preservation methods are key factors influencing the results of liver transplantation. In this study, the outcomes of experimental models receiving donation after cardiac death (DCD) livers preserved through machine perfusion (MP) or static cold storage (CS) were compared by conducting a meta-analysis. Standardized mean difference (SMD) and 95% confidence interval (CI) were calculated to compare pooled data from two animal species. Twenty-four studies involving MP preservation were included in the meta-analysis. Compared with CS preservation, MP can reduce the levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), and hyaluronic acid (HA) and the changes in liver weight. By contrast, MP can enhance bile production and portal vein flow (PVF). Alkaline phosphatase (ALP) levels and histological changes significantly differed between the two preservation methods. In conclusion, MP of DCD livers is superior to CS in experimental animals.

Entities:  

Keywords:  DCD; cold storage; machine perfusion; meta-analysis

Mesh：

Substances：

Year:  2016        PMID： 27837413     DOI： 10.1007/s11684-016-0474-7

Source DB:  PubMed          Journal:  Front Med        ISSN： 2095-0217            Impact factor:   4.592


  54 in total

1.  Advantages of normothermic perfusion over cold storage in liver preservation.

Authors:  Charles J Imber; Shawn D St Peter; Inigo Lopez de Cenarruzabeitia; Dave Pigott; Tim James; Richard Taylor; James McGuire; David Hughes; Andrew Butler; Michael Rees; Peter J Friend
Journal:  Transplantation       Date:  2002-03-15       Impact factor: 4.939

2.  Hypothermic machine preservation attenuates ischemia/reperfusion markers after liver transplantation: preliminary results.

Authors:  James V Guarrera; Scot D Henry; Sean W C Chen; Tod Brown; Eugenia Nachber; Ben Arrington; Jason Boykin; Benjamin Samstein; Robert S Brown; Jean C Emond; H Thomas Lee
Journal:  J Surg Res       Date:  2010-02-21       Impact factor: 2.192

Review 3.  Preservation and reperfusion injuries in liver allografts. An overview and synthesis of current studies.

Authors:  P A Clavien; P R Harvey; S M Strasberg
Journal:  Transplantation       Date:  1992-05       Impact factor: 4.939

4.  Machine perfusion of the liver: maintenance of mitochondrial function after 48-hour preservation.

Authors:  J S Kim; K Boudjema; A D'Alessandro; J H Southard
Journal:  Transplant Proc       Date:  1997-12       Impact factor: 1.066

5.  Risk stratification of kidneys from donation after cardiac death donors and the utility of machine perfusion.

Authors:  A W Cantafio; A A S Dick; J B Halldorson; R Bakthavatsalam; J D Reyes; J D Perkins
Journal:  Clin Transplant       Date:  2011-05-18       Impact factor: 2.863

6.  Hypothermic machine preservation in human liver transplantation: the first clinical series.

Authors:  J V Guarrera; S D Henry; B Samstein; R Odeh-Ramadan; M Kinkhabwala; M J Goldstein; L E Ratner; J F Renz; H T Lee; R S Brown; J C Emond
Journal:  Am J Transplant       Date:  2009-12-02       Impact factor: 8.086

7.  Pronlonged hypothermic machine perfusion preserves hepatocellular function but potentiates endothelial cell dysfunction in rat livers.

Authors:  Hongzhi Xu; Charles Y Lee; Mark G Clemens; Jian X Zhang
Journal:  Transplantation       Date:  2004-06-15       Impact factor: 4.939

8.  Hypothermic perfusion preservation of liver: the role of phosphate in stimulating ATP synthesis studied by 31P NMR.

Authors:  C J Lockett; B J Fuller; A L Busza; E Proctor
Journal:  Transpl Int       Date:  1995       Impact factor: 3.782

9.  Machine perfusion or cold storage in deceased-donor kidney transplantation.

Authors:  Cyril Moers; Jacqueline M Smits; Mark-Hugo J Maathuis; Jürgen Treckmann; Frank van Gelder; Bogdan P Napieralski; Margitta van Kasterop-Kutz; Jaap J Homan van der Heide; Jean-Paul Squifflet; Ernest van Heurn; Günter R Kirste; Axel Rahmel; Henri G D Leuvenink; Andreas Paul; Jacques Pirenne; Rutger J Ploeg
Journal:  N Engl J Med       Date:  2009-01-01       Impact factor: 91.245

10.  Machine perfusion versus cold storage of kidneys derived from donation after cardiac death: a meta-analysis.

Authors:  Ronghai Deng; Guangxiang Gu; Dongping Wang; Qiang Tai; Linwei Wu; Weiqiang Ju; Xiaofeng Zhu; Zhiyong Guo; Xiaoshun He
Journal:  PLoS One       Date:  2013-03-11       Impact factor: 3.240
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  5 in total

Review 1.  Hospital-Based Health Technology Assessment of Machine Perfusion Systems for Human Liver Transplantation.

Authors:  Paolo De Simone; Davide Ghinolfi
Journal:  Transpl Int       Date:  2022-05-27       Impact factor: 3.842

Review 2.  Tissue conservation for transplantation.

Authors:  Nicco Krezdorn; Sotirios Tasigiorgos; Luccie Wo; Marvee Turk; Rachel Lopdrup; Harriet Kiwanuka; Thet-Su Win; Ericka Bueno; Bohdan Pomahac
Journal:  Innov Surg Sci       Date:  2017-08-08

3.  A Systematic Review and Meta-Analysis of Machine Perfusion vs. Static Cold Storage of Liver Allografts on Liver Transplantation Outcomes: The Future Direction of Graft Preservation.

Authors:  Junjun Jia; Yu Nie; Jianhui Li; Haiyang Xie; Lin Zhou; Jun Yu; Shu-Sen Zheng
Journal:  Front Med (Lausanne)       Date:  2020-05-12

4.  Optimizing Livers for Transplantation Using Machine Perfusion versus Cold Storage in Large Animal Studies and Human Studies: A Systematic Review and Meta-Analysis.

Authors:  Xinan Jiang; Lei Feng; Mingxin Pan; Yi Gao
Journal:  Biomed Res Int       Date:  2018-09-05       Impact factor: 3.411

5.  Mitochondrial Consequences of Organ Preservation Techniques during Liver Transplantation.

Authors:  Tamara Horváth; Dávid Kurszán Jász; Bálint Baráth; Marietta Zita Poles; Mihály Boros; Petra Hartmann
Journal:  Int J Mol Sci       Date:  2021-03-10       Impact factor: 5.923
  5 in total

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