John B Harringa1, Rebecca L Bracken2, Scott K Nagle3, Mark L Schiebler3, Brian W Patterson1, James E Svenson1, Michael D Repplinger4. 1. University of Wisconsin-Madison, BerbeeWalsh Department of Emergency Medicine. 2. University of Wisconsin-Madison, BerbeeWalsh Department of Emergency Medicine. Electronic address: rbracken@medicine.wisc.edu. 3. University of Wisconsin-Madison, Department of Radiology. 4. University of Wisconsin-Madison, BerbeeWalsh Department of Emergency Medicine; University of Wisconsin-Madison, Department of Radiology.
Abstract
OBJECTIVE: Our aim was to validate the previously published claim of a positive relationship between low blood hemoglobin level (anemia) and pulmonary embolism (PE). METHODS: This was a retrospective study of patients undergoing cross-sectional imaging to evaluate for PE at an academic medical center. Patients were identified using billing records for charges attributed to either magnetic resonance angiography or computed tomography angiography of the chest from 2008 to 2013. The main outcome measure was mean hemoglobin levels among those with and without PE. Our reference standard for PE status included index imaging results and a 6-month clinical follow-up for the presence of interval venous thromboembolism, conducted via review of the electronic medical record. Secondarily, we performed a subgroup analysis of only those patients who were seen in the emergency department. Finally, we again compared mean hemoglobin levels when limiting our control population to an age- and sex-matched cohort of the included cases. RESULTS: There were 1294 potentially eligible patients identified, of whom 121 were excluded. Of the remaining 1173 patients, 921 had hemoglobin levels analyzed within 24 hours of their index scan and thus were included in the main analysis. Of those 921 patients, 107 (11.6%; 107/921) were positive for PE. We found no significant difference in mean hemoglobin level between those with and without PE regardless of the control group used (12.4 ± 2.1 g/dL and 12.3 ± 2.0 g/dL [P = .85], respectively). CONCLUSIONS: Our data demonstrated no relationship between anemia and PE.
OBJECTIVE: Our aim was to validate the previously published claim of a positive relationship between low blood hemoglobin level (anemia) and pulmonary embolism (PE). METHODS: This was a retrospective study of patients undergoing cross-sectional imaging to evaluate for PE at an academic medical center. Patients were identified using billing records for charges attributed to either magnetic resonance angiography or computed tomography angiography of the chest from 2008 to 2013. The main outcome measure was mean hemoglobin levels among those with and without PE. Our reference standard for PE status included index imaging results and a 6-month clinical follow-up for the presence of interval venous thromboembolism, conducted via review of the electronic medical record. Secondarily, we performed a subgroup analysis of only those patients who were seen in the emergency department. Finally, we again compared mean hemoglobin levels when limiting our control population to an age- and sex-matched cohort of the included cases. RESULTS: There were 1294 potentially eligible patients identified, of whom 121 were excluded. Of the remaining 1173 patients, 921 had hemoglobin levels analyzed within 24 hours of their index scan and thus were included in the main analysis. Of those 921 patients, 107 (11.6%; 107/921) were positive for PE. We found no significant difference in mean hemoglobin level between those with and without PE regardless of the control group used (12.4 ± 2.1 g/dL and 12.3 ± 2.0 g/dL [P = .85], respectively). CONCLUSIONS: Our data demonstrated no relationship between anemia and PE.
Authors: Wim Lucassen; Geert-Jan Geersing; Petra M G Erkens; Johannes B Reitsma; Karel G M Moons; Harry Büller; Henk C van Weert Journal: Ann Intern Med Date: 2011-10-04 Impact factor: 25.391
Authors: Paul A Harris; Robert Taylor; Robert Thielke; Jonathon Payne; Nathaniel Gonzalez; Jose G Conde Journal: J Biomed Inform Date: 2008-09-30 Impact factor: 6.317
Authors: Frederick A Spencer; Cathy Emery; Darleen Lessard; Frederick Anderson; Sri Emani; Jayashri Aragam; Richard C Becker; Robert J Goldberg Journal: J Gen Intern Med Date: 2006-07 Impact factor: 5.128
Authors: Francis M Fesmire; Michael D Brown; James A Espinosa; Richard D Shih; Scott M Silvers; Stephen J Wolf; Wyatt W Decker Journal: Ann Emerg Med Date: 2011-06 Impact factor: 5.721
Authors: Marja K Puurunen; Philimon N Gona; Martin G Larson; Joanne M Murabito; Jared W Magnani; Christopher J O'Donnell Journal: Thromb Res Date: 2016-06-29 Impact factor: 3.944
Authors: Ralph C Wang; Stephen Bent; Ellen Weber; Jersey Neilson; Rebecca Smith-Bindman; Jahan Fahimi Journal: Ann Emerg Med Date: 2015-12-31 Impact factor: 5.721
Authors: David Jiménez; Carlos Escobar; David Martí; Gema Díaz; Jesús César; Angel García-Avello; Antonio Sueiro; Roger D Yusen Journal: Thromb Haemost Date: 2009-07 Impact factor: 5.249
Authors: Grégoire Le Gal; Marc Righini; Pierre-Marie Roy; Olivier Sanchez; Drahomir Aujesky; Henri Bounameaux; Arnaud Perrier Journal: Ann Intern Med Date: 2006-02-07 Impact factor: 25.391
Authors: Satyajeet Roy; Han Le; Ayobamidele Balogun; Elizabeth Caskey; Thomas Tessitore; Rasagnya Kota; Janice Hejirika; Siyuan Yu; Long Nguyen; Andrew Louis Lazo; Christopher Yard; Michael Monaghan; Menaka Dhingra; Sneha Modi; Krystal Hunter Journal: J Clin Med Res Date: 2020-03-02