Shi-Wei Yang1, Rebecca R Hennessy2, Sundeep Khosla3, Ryan Lennon4, Darrell Loeffler2, Tao Sun2, Zhi Liu2, Kyoung-Ha Park2, Fei-Long Wang2, Lilach O Lerman5, Amir Lerman6. 1. Department of Cardiovascular Diseases, Mayo Clinic and College of Medicine, Rochester, MN 55905, USA; 12(th) Ward, Department of Cardiology, Beijing An Zhen Hospital, Capital Medical University, Beijing 100029, China; Atherosclerosis Research Center, Beijing Institute of Heart Lung and Blood Vessel Disease, Beijing 100029, China; The Key Laboratory of Remodeling-related Cardiovascular Disease, Ministry of Education, Beijing 100029, China. 2. Department of Cardiovascular Diseases, Mayo Clinic and College of Medicine, Rochester, MN 55905, USA. 3. Department of Endocrinology, Mayo Clinic and College of Medicine, Rochester, MN 55905, USA. 4. Department of Biomedical Statistics, Mayo Clinic and College of Medicine, Rochester, MN 55905, USA. 5. Department of Nephrology and Hypertension, Mayo Clinic and College of Medicine, Rochester, MN 55905, USA. 6. Department of Cardiovascular Diseases, Mayo Clinic and College of Medicine, Rochester, MN 55905, USA. Electronic address: lerman.amir@mayo.edu.
Abstract
BACKGROUND: There is increasing evidence implying that the early and functionally highly active circulating endothelial progenitor cell (CEPC) phenotype (CD34-/CD133+/KDR+) with osteogenic potential (OCN+) might link between vascular atherosclerotic calcification and mechanisms of bone metabolism. We sought to evaluate the early OCN+ CEPC counts as an independent biomarker for the severity of coronary artery disease (CAD). METHODS: Peripheral blood samples were drawn from 593 patients undergoing clinically indicated coronary angiography. CAD severity was assessed by the presence of significant coronary artery stenosis (CAS) as well as an ordinal categorical variable. Subjects were followed for all-cause death over a median follow-up of 40months. RESULTS: OCN+ early CEPC counts (square-root transformed) were independently associated with the presence of significant CAS [odds ratio (OR) per standard deviation (SD) increment: 1.389, 95% confidence interval [CI]: 1.131 to 1.707, p=0.002). Similar association was observed with an increase in levels of CAS (OR: 1.353, 95% CI: 1.157 to 1.582, p<0.001). There was a weak tendency between OCN+ early CEPC counts and all-cause mortality (p=0.090), whereas the highest decile of OCN+ early CEPC counts had a 2.991-fold increased risk of all-cause death (p=0.047). CONCLUSIONS: We demonstrate for the first time an independent, significant, and strong correlation between OCN+ early CEPC counts and CAD severity. Additionally, very high numbers of OCN+ early CEPC tend to be linked to the risk of all-cause mortality.
BACKGROUND: There is increasing evidence implying that the early and functionally highly active circulating endothelial progenitor cell (CEPC) phenotype (CD34-/CD133+/KDR+) with osteogenic potential (OCN+) might link between vascular atherosclerotic calcification and mechanisms of bone metabolism. We sought to evaluate the early OCN+ CEPC counts as an independent biomarker for the severity of coronary artery disease (CAD). METHODS: Peripheral blood samples were drawn from 593 patients undergoing clinically indicated coronary angiography. CAD severity was assessed by the presence of significant coronary artery stenosis (CAS) as well as an ordinal categorical variable. Subjects were followed for all-cause death over a median follow-up of 40months. RESULTS:OCN+ early CEPC counts (square-root transformed) were independently associated with the presence of significant CAS [odds ratio (OR) per standard deviation (SD) increment: 1.389, 95% confidence interval [CI]: 1.131 to 1.707, p=0.002). Similar association was observed with an increase in levels of CAS (OR: 1.353, 95% CI: 1.157 to 1.582, p<0.001). There was a weak tendency between OCN+ early CEPC counts and all-cause mortality (p=0.090), whereas the highest decile of OCN+ early CEPC counts had a 2.991-fold increased risk of all-cause death (p=0.047). CONCLUSIONS: We demonstrate for the first time an independent, significant, and strong correlation between OCN+ early CEPC counts and CAD severity. Additionally, very high numbers of OCN+ early CEPC tend to be linked to the risk of all-cause mortality.
Authors: Anna Pyšná; Robert Bém; Andrea Němcová; Vladimíra Fejfarová; Alexandra Jirkovská; Jitka Hazdrová; Edward B Jude; Michal Dubský Journal: Stem Cell Rev Rep Date: 2019-04 Impact factor: 5.739
Authors: Sophie A Millar; Hinal Patel; Susan I Anderson; Timothy J England; Saoirse E O'Sullivan Journal: Front Endocrinol (Lausanne) Date: 2017-07-31 Impact factor: 5.555
Authors: Filippo Romanelli; AnthonyMarco Corbo; Maryam Salehi; Manisha C Yadav; Soha Salman; David Petrosian; Omid J Rashidbaigi; Jesse Chait; Jes Kuruvilla; Maria Plummer; Ilian Radichev; Kenneth B Margulies; A Martin Gerdes; Anthony B Pinkerton; José Luis Millán; Alexei Y Savinov; Olga V Savinova Journal: PLoS One Date: 2017-10-12 Impact factor: 3.240