Thaise Campos Mondin1, Taiane de Azevedo Cardoso2, Fernanda Pedrotti Moreira1, Carolina Wiener1, Jean Pierre Oses3, Luciano Dias de Mattos Souza1, Karen Jansen4, Pedro Vieira da Silva Magalhães5, Flávio Kapczinski5, Ricardo Azevedo da Silva6. 1. Translational Science on Brain Disorders, Department of Health and Behavior, Catholic University of Pelotas, 373 Gonçalves Chaves, 416C, Pelotas, RS 96015-560, Brazil. 2. Universidade Federal do Rio Grande do Sul, Departamento de psiquiatria e medicina legal, Brazil. 3. Translational Science on Brain Disorders, Department of Health and Behavior, Catholic University of Pelotas, 373 Gonçalves Chaves, 416C, Pelotas, RS 96015-560, Brazil; Department of Psychiatry and Behavioral Sciences, Center For Translational Psychiatry, UT Center of Excellence on Mood Disorders, 1941 East Road, BBSB 5102, Houston, TX 77054, United States. 4. Translational Science on Brain Disorders, Department of Health and Behavior, Catholic University of Pelotas, 373 Gonçalves Chaves, 416C, Pelotas, RS 96015-560, Brazil; Universidade Federal do Rio Grande do Sul, Departamento de psiquiatria e medicina legal, Brazil. 5. Universidade Federal do Rio Grande do Sul, Departamento de psiquiatria e medicina legal, Brazil; Department of Psychiatry and Behavioral Sciences, Center For Translational Psychiatry, UT Center of Excellence on Mood Disorders, 1941 East Road, BBSB 5102, Houston, TX 77054, United States. 6. Translational Science on Brain Disorders, Department of Health and Behavior, Catholic University of Pelotas, 373 Gonçalves Chaves, 416C, Pelotas, RS 96015-560, Brazil. Electronic address: ricardo.as@uol.com.br.
Abstract
OBJECTIVE: To assess circadian preference among a community sample of people with bipolar disorder, major depression and without any mood disorders. Secondly, we investigated the association of circadian preference with cytokines interleukin-6 (IL-6), interleukin-10 (IL-10) and, tumor necrosis factor alpha (TNF-α) and oxidative stress assessed by thiobarbituric acid reactive substances (TBARS), uric acid and Protein Carbonyl Content (PCC). METHOD: A cross-sectional study nested in a population-based sample. Caseness was confirmed with the Structured Clinical Interview for DSM-IV. A sample of 215 participants, in whom we measured circadian preferences, IL-6, IL-10, TNF-α, TBARS, uric acid, PCC. Biological rhythms were evaluated using the Biological Interview of Assessment in Neuropsychiatry. RESULTS: Bipolar group presented a higher alteration in biological rhythms (40.40±9.78) when compared with the major depression group (36.35±9.18) and control group (27.61±6.89) p<0.001. Subjects with bipolar disorder who were active at night and had a day/night cycle reverse showed decreased levels of IL-6 (t, 44=2.096; p=0.042), (t, 44=2.213; p=0.032), respectively. In the bipolar disorder group subjects who presented day/night cycle reverse had lower TBARS levels (t, 41=2.612; p=0.013). TNF-α were decreased in subjects more active at night with bipolar disorder. CONCLUSION: Lower serum levels of IL-6, TNF-α and TBARS were associated with evening preference in bipolar disorder group. These findings suggest that chronotype may alter the levels of interleukins and oxidative stress levels in bipolar and healthy subjects. A better understanding of the role of circadian preferences in levels of interleukins and oxidative stress are needed. Copyright Â
OBJECTIVE: To assess circadian preference among a community sample of people with bipolar disorder, major depression and without any mood disorders. Secondly, we investigated the association of circadian preference with cytokines interleukin-6 (IL-6), interleukin-10 (IL-10) and, tumor necrosis factor alpha (TNF-α) and oxidative stress assessed by thiobarbituric acid reactive substances (TBARS), uric acid and Protein Carbonyl Content (PCC). METHOD: A cross-sectional study nested in a population-based sample. Caseness was confirmed with the Structured Clinical Interview for DSM-IV. A sample of 215 participants, in whom we measured circadian preferences, IL-6, IL-10, TNF-α, TBARS, uric acid, PCC. Biological rhythms were evaluated using the Biological Interview of Assessment in Neuropsychiatry. RESULTS:Bipolar group presented a higher alteration in biological rhythms (40.40±9.78) when compared with the major depression group (36.35±9.18) and control group (27.61±6.89) p<0.001. Subjects with bipolar disorder who were active at night and had a day/night cycle reverse showed decreased levels of IL-6 (t, 44=2.096; p=0.042), (t, 44=2.213; p=0.032), respectively. In the bipolar disorder group subjects who presented day/night cycle reverse had lower TBARS levels (t, 41=2.612; p=0.013). TNF-α were decreased in subjects more active at night with bipolar disorder. CONCLUSION: Lower serum levels of IL-6, TNF-α and TBARS were associated with evening preference in bipolar disorder group. These findings suggest that chronotype may alter the levels of interleukins and oxidative stress levels in bipolar and healthy subjects. A better understanding of the role of circadian preferences in levels of interleukins and oxidative stress are needed. Copyright Â
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