Literature DB >> 27836058

Mechanism-Based Strategies for the Management of Autoimmunity and Immune Dysregulation in Primary Immunodeficiencies.

Jolan E Walter1, Jocelyn R Farmer2, Zsofia Foldvari3, Troy R Torgerson4, Megan A Cooper5.   

Abstract

A broad spectrum of autoimmunity is now well described in patients with primary immunodeficiencies (PIDs). Management of autoimmune disease in the background of PID is particularly challenging given the seemingly discordant goals of immune support and immune suppression. Our growing ability to define the molecular underpinnings of immune dysregulation has facilitated novel targeted therapeutics. This review focuses on mechanism-based treatment strategies for the most common autoimmune and inflammatory complications of PID including autoimmune cytopenias, rheumatologic disease, and gastrointestinal disease. We aim to provide guidance regarding the rational use of these agents in the complex PID patient population.
Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Arthritis; Autoimmune enteropathy (AIE); Autoimmunity; Cytopenias; Inflammatory bowel disease (IBD); Lupus; Primary immunodeficiencies (PIDs); Treatment; Vasculitis

Mesh：

Year:  2016        PMID： 27836058      PMCID： PMC5289744          DOI： 10.1016/j.jaip.2016.08.004

Source DB:  PubMed          Journal:  J Allergy Clin Immunol Pract


  185 in total

1.  Mechanistic target of rapamycin complex 1 expands Th17 and IL-4+ CD4-CD8- double-negative T cells and contracts regulatory T cells in systemic lupus erythematosus.

Authors:  Hiroshi Kato; Andras Perl
Journal:  J Immunol       Date:  2014-03-28       Impact factor: 5.422

Review 2.  Bruton's tyrosine kinase--an integral protein of B cell development that also has an essential role in the innate immune system.

Authors:  Gabriela López-Herrera; Alexander Vargas-Hernández; Maria Edith González-Serrano; Laura Berrón-Ruiz; Juan Carlos Rodríguez-Alba; Francisco Espinosa-Rosales; Leopoldo Santos-Argumedo
Journal:  J Leukoc Biol       Date:  2013-11-18       Impact factor: 4.962

Review 3.  DOCK8 deficiency.

Authors:  Helen C Su; Huie Jing; Qian Zhang
Journal:  Ann N Y Acad Sci       Date:  2011-12       Impact factor: 5.691

4.  Antibody deficiency and autoimmunity in 22q11.2 deletion syndrome.

Authors:  A R Gennery; D Barge; J J O'Sullivan; T J Flood; M Abinun; A J Cant
Journal:  Arch Dis Child       Date:  2002-06       Impact factor: 3.791

5.  Clinical characteristics and genotype-phenotype correlation in 62 patients with X-linked agammaglobulinemia.

Authors:  Pamela P W Lee; Tong-Xin Chen; Li-Ping Jiang; Koon-Wing Chan; Wanling Yang; Bee-Wah Lee; Wen-Chin Chiang; Xiang-Yuan Chen; Susanna F S Fok; Tsz-Leung Lee; Marco H K Ho; Xi-Qiang Yang; Yu-Lung Lau
Journal:  J Clin Immunol       Date:  2009-11-11       Impact factor: 8.317

6.  Use of rituximab for refractory cytopenias associated with autoimmune lymphoproliferative syndrome (ALPS).

Authors:  V Koneti Rao; Susan Price; Katie Perkins; Patricia Aldridge; Jean Tretler; Joie Davis; Janet K Dale; Fred Gill; Kip R Hartman; Linda C Stork; David J Gnarra; Lakshmanan Krishnamurti; Peter E Newburger; Jennifer Puck; Thomas Fleisher
Journal:  Pediatr Blood Cancer       Date:  2009-07       Impact factor: 3.167

7.  Clinical, immunological and molecular characterization of DOCK8 and DOCK8-like deficient patients: single center experience of twenty-five patients.

Authors:  Zobaida Alsum; Abbas Hawwari; Osama Alsmadi; Safa Al-Hissi; Esteban Borrero; Asma' Abu-Staiteh; Hanif G Khalak; Salma Wakil; Abdelmoneim M Eldali; Rand Arnaout; Abdulaziz Al-Ghonaium; Saleh Al-Muhsen; Hasan Al-Dhekri; Bandar Al-Saud; Hamoud Al-Mousa
Journal:  J Clin Immunol       Date:  2012-09-12       Impact factor: 8.317

8.  STIM1 mutation associated with a syndrome of immunodeficiency and autoimmunity.

Authors:  Capucine Picard; Christie-Ann McCarl; Alexander Papolos; Sara Khalil; Kevin Lüthy; Claire Hivroz; Francoise LeDeist; Frédéric Rieux-Laucat; Gideon Rechavi; Anjana Rao; Alain Fischer; Stefan Feske
Journal:  N Engl J Med       Date:  2009-05-07       Impact factor: 91.245

9.  Long-term outcome following hematopoietic stem-cell transplantation in Wiskott-Aldrich syndrome: collaborative study of the European Society for Immunodeficiencies and European Group for Blood and Marrow Transplantation.

Authors:  Hulya Ozsahin; Marina Cavazzana-Calvo; Luigi D Notarangelo; Ansgar Schulz; Adrian J Thrasher; Evelina Mazzolari; Mary A Slatter; Francoise Le Deist; Stephane Blanche; Paul Veys; Anders Fasth; Robbert Bredius; Petr Sedlacek; Nico Wulffraat; Juan Ortega; Carsten Heilmann; Anne O'Meara; Jacek Wachowiak; Krzysztof Kalwak; Susanne Matthes-Martin; Tayfun Gungor; Aydan Ikinciogullari; Paul Landais; Andrew J Cant; Wilhelm Friedrich; Alain Fischer
Journal:  Blood       Date:  2007-09-27       Impact factor: 22.113

10.  Long-term follow-up and outcome of a large cohort of patients with common variable immunodeficiency.

Authors:  Isabella Quinti; Annarosa Soresina; Giuseppe Spadaro; Silvana Martino; Simona Donnanno; Carlo Agostini; Pignata Claudio; Dammacco Franco; Anna Maria Pesce; Federica Borghese; Andrea Guerra; Roberto Rondelli; Alessandro Plebani
Journal:  J Clin Immunol       Date:  2007-02-14       Impact factor: 8.542
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  21 in total

Review 1.  Inflammatory consequences of inherited disorders affecting neutrophil function.

Authors:  Mary C Dinauer
Journal:  Blood       Date:  2019-03-21       Impact factor: 22.113

2.  Primary Immunodeficiency: New Insights and Practical Clinical Approaches.

Authors:  Charlotte Cunningham-Rundles
Journal:  J Allergy Clin Immunol Pract       Date:  2016 Nov - Dec

Review 3.  Treatment of immune-mediated cytopenias in patients with primary immunodeficiencies and immune regulatory disorders (PIRDs).

Authors:  Markus G Seidel
Journal:  Hematology Am Soc Hematol Educ Program       Date:  2020-12-04

Review 4.  How to evaluate for immunodeficiency in patients with autoimmune cytopenias: laboratory evaluation for the diagnosis of inborn errors of immunity associated with immune dysregulation.

Authors:  Roshini S Abraham
Journal:  Hematology Am Soc Hematol Educ Program       Date:  2020-12-04

Review 5.  Rituximab and eculizumab when treating nonmalignant hematologic disorders: infection risk, immunization recommendations, and antimicrobial prophylaxis needs.

Authors:  Elissa R Engel; Jolan E Walter
Journal:  Hematology Am Soc Hematol Educ Program       Date:  2020-12-04

Review 6.  Autoimmunity in Primary Immunodeficiencies (PID).

Authors:  Grace T Padron; Vivian P Hernandez-Trujillo
Journal:  Clin Rev Allergy Immunol       Date:  2022-06-01       Impact factor: 8.667

7.  Underlying Inborn Errors of Immunity in Patients With Evans Syndrome and Multilineage Cytopenias: A Single-Centre Analysis.

Authors:  Maurizio Miano; Daniela Guardo; Alice Grossi; Elena Palmisani; Francesca Fioredda; Paola Terranova; Enrico Cappelli; Michela Lupia; Monica Traverso; Gianluca Dell'Orso; Fabio Corsolini; Andrea Beccaria; Marina Lanciotti; Isabella Ceccherini; Carlo Dufour
Journal:  Front Immunol       Date:  2022-05-17       Impact factor: 8.786

Review 8.  Autoimmune enteropathies.

Authors:  Sarah E Umetsu; Ian Brown; Cord Langner; Gregory Y Lauwers
Journal:  Virchows Arch       Date:  2017-10-11       Impact factor: 4.064

9.  Primary Immunodeficiency in Children With Autoimmune Cytopenias: Retrospective 154-Patient Cohort.

Authors:  Emma Westermann-Clark; Cristina Adelia Meehan; Anna K Meyer; Joseph F Dasso; Devendra Amre; Maryssa Ellison; Bhumika Patel; Marisol Betensky; Charles Isaac Hauk; Jennifer Mayer; Jonathan Metts; Jennifer W Leiding; Panida Sriaroon; Ambuj Kumar; Irmel Ayala; Jolan E Walter
Journal:  Front Immunol       Date:  2021-04-22       Impact factor: 7.561

Review 10.  Primary immune regulatory disorders: a growing universe of immune dysregulation.

Authors:  Alice Y Chan; Troy R Torgerson
Journal:  Curr Opin Allergy Clin Immunol       Date:  2020-12
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