Characterisation of carbapenem-resistant Enterobacteriaceae from the southwestern Ohio, northern Kentucky and southeastern Indiana region.

Although carbapenem-resistant Enterobacteriaceae (CRE) have been recognised worldwide, there are important gaps in regional prevalence data. This study sought to determine the occurrence and type of CRE in the Cincinnati tri-state region. Clinical microbiology laboratories in the region screened patient stool and rectal swab samples using chromogenic screening agar. Isolates of Enterobacteriaceae resistant to carbapenems were characterised using molecular methods. Area institutions screened 1939 patient samples. Of 18 Enterobacteriaceae that grew on the screening agar, 8 isolates were resistant to one or all carbapenems and 6 isolates (all Klebsiella spp.) tested positive for a blaKPC gene. This study provides guidance on the prevalence of KPC and the genetic characteristics of carbapenem-resistant Klebsiella pneumoniae isolates in the Cincinnati tri-state area. Additional similar local epidemiology studies are warranted to provide an understanding and control of the spread of CRE. Copyright Â